RT Journal Article SR Electronic T1 In Vitro Analysis of the Effect of In-Line 1.2 Micron Filters on Two Formulations of Propofol (2,6-Diisopropyl Phenol) JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 297 OP 306 DO 10.5731/pdajpst.2015.01033 VO 69 IS 2 A1 Ross A. Kennedy A1 Michelle L. Kennedy A1 Hana Morrissey A1 Patrick A. Ball YR 2015 UL http://journal.pda.org/content/69/2/297.abstract AB Recent evidence has shown improved outcomes in pediatric intensive care units with the intensive use of intravenous in-line filtration. This has caused resurgence in interest in filter use but has raised questions in relation to emulsion-based formulations such as propofol. Our objective was to test two propofol products, Diprivan® and Fresofol®, with the Pall Lipipor® TNA and Lipipor NLF intravenous in-line filters and to assay the content before and after filtration under typical infusion conditions. The propofol emulsions were delivered from a 50 mL syringe through an extension set and into either a Lipipor TNA (50 mL/h–1) or Lipipor NLF (20 mL/h–1) filter. Samples were taken at regular intervals and assayed using a high-performance liquid chromatography method before and after filtration. No evidence was found of a significant concentration change during passage of either product through either model of filter. Propofol from two products was found to pass through two different types of Pall 1.2 μm intravenous in-line filters. There was no significant change in concentration before and after filtration under typical conditions of administration. In conclusion, administration of these products through these models of in-line filter would be safe and effective.