PT  - JOURNAL ARTICLE
AU  - Ramnarine, Emma
AU  - Busse, Ursula
AU  - Chassant, Franck
AU  - Colao, Marcello
AU  - Edwards, Julia
AU  - O'Donnell, Kevin
AU  - Jornitz, Maik
AU  - Munk, Morten
AU  - Seymour, Melissa
AU  - Simianu, Mihaela
AU  - Skeens, Lisa
AU  - Vinther, Anders
TI  - PDA Points to Consider: Technical Product Lifecycle Management Pharmaceutical Quality System Effectiveness For Managing Post-Approval Changes
AID  - 10.5731/pdajpst.2017.007575
DP  - 2017 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - pdajpst.2017.007575
4099  - http://journal.pda.org/content/early/2017/02/14/pdajpst.2017.007575.short
4100  - http://journal.pda.org/content/early/2017/02/14/pdajpst.2017.007575.full
AB  - The International Council for Harmonisation Quality Guideline 10 (ICH Q10) describes the Pharmaceutical Quality System (PQS), indicating it is intended to apply throughout a product's lifecycle, in conjunction with good manufacturing practice (GMP) requirements, in order to achieve quality in a consistent and reproducible manner. Implementation of an effective PQS is essential for a company to achieve product realization, establish and maintain a state of control, and facilitate continual improvement (1). When changes are made during the commercial life of a product, an effective PQS, product and process understanding, and use of quality risk management should ensure that product quality, patient safety, and adequate supply to patients are maintained; this, according to ICH Q10-Annex 1, should provide companies the opportunity to manage post-approval changes (PAC) with reduced regulatory oversight (1). But what exactly constitutes an effective PQS? And how does it support change management for PACs? This paper intends to answer these questions and guide companies to seize the opportunities outlined in ICH Q10-Annex 1, to manage product and process changes within the PQS, and downgrade the level of regulatory submission required. This is the second of a series of PDA "Points to Consider" papers on technical product lifecycle management; the first paper focused on the technical product lifecycle management strategy including communication and knowledge exchange between Marketing Authorization Holders and Health Authorities.