Combinations for Initial Time Study. Stoppers and seals were West Pharmaceutical Services, Inc. products.a Compression targets were low, medium, and high corresponding to approximately 10%–15%, 20%–35%, and 25%–40% for 20 mm stoppers and 20%–30%, 45%–55%, and 50%–60% for 13 mm stoppers, respectively. These corresponded to residual seal force values of 5–18 lbs.
| Rubber Formulation | Stopper Size [mm] (Configuration) | Glass Vial Type (Blowback) | Glass Vial Size |
|---|---|---|---|
| Serum | |||
| 4023/50 Gray | 13 (ART 1104) | Straightwall | 2R |
| 20 (ART 1071) | Straightwall | 6R | |
| 20 (ART 1343, F-Tec)b | US | 6R | |
| 4432/50 Gray | 13 (S2-F451, F-Tec) | US | 2R |
| 13 (V-35) | EU | 2R | |
| 20 (S-127) | EU | 6R | |
| Lyophilization | |||
| 4023/50 Gray | 13 (ART 1079) | Straightwall | 2R |
| 13 (ART 1356, F-Tec) | US | 2R | |
| 20 (ART 1319) | Straightwall | 6R | |
| 20 (ART 1346, F-Tec) | US | 6R | |
| 4432/50 Gray | 13 (V2-F451W, F-Tec) | EU | 2R |
| 20 (V10-F597, F-Tec) | EU | 6R | |