TABLE II

Hansen Solubility Parameter Distances (MPa1/2) between Key Excipients, Silicone Oil, Water, and Borosilicate Glass Demonstrating Strong (red), Medium (blue), and Weak (black) Interactions

Silicone OilGlassWaterMannitolNaClPS 80a
Silicone oil0
Glass11.600
Water18.5217.580
Mannitol18.1219.254.070
NaCl22.8221.515.06N/Ab0
PS 804.258.5711.9412.6616.520
Acetic acid11.465.6112.0913.7315.955.48
Histidine15.5214.475.408.1610.388.63
Citric acid23.2117.8610.7514.8413.2415.99

  • ↵a PS 80, polysorbate 80.

  • ↵b N/A, not applicable.