TABLE I

Hansen Solubility Parameters for Key Excipients, Silicone Oil, Water, and Borosilicate Glassa

MaterialNonpolar Component δd (MPa1/2)Polar Component δp (MPa1/2)H-Bonding Component δh (MPa1/2)
Acetic acid14.58.013.5
Histidine18.611.817.03
Citric acid17.611.3625.98
Mannitol18.5119.1413.48
NaCl17.6421.9518.03
PS 80b (Combined)16.76.59.4
PS 80 (Hydrophobic Part)16.30.71.7
PS 80 (Hydrophilic Part)16.87.310.6
Silicone oil 114.01.01.0
Silicone oil 217.04.04.0
Borosilicate glass13.253.0312.79
Water18.117.116.9
  • a References 1315.

  • b PS 80, polysorbate 80.