TABLE I

Overview of the Different Dosing System Characteristics

CriteriaPiston PumpTime-Pressure SystemRadial PeristalticLinear Peristaltic
Filling Accuracy < 100 µL+ +a– ––+ +
Fill Volumes < 100 µL+– ––+ +
Fill Volume Range– –++ ++ +
CIP/SIP Complexityb– –++ ++ +
Single-Use Compatible– –+ ++ ++ +
Product Stress– –+++ +
Interfacial Stress– –– –+ ++ +
Maintenance–+++

  • ↵a + is favorable, − is unfavorable.

  • ↵b CIP is clean-in-place; SIP is sterilize-in-place.