Hansen Solubility Parameter Distances (MPa1/2) between Key Excipients, Silicone Oil, Water, and Borosilicate Glass Demonstrating Strong (italic), Medium (bold), and Weak (bold-italic) Interactions
| Silicone Oil | Glass | Water | Mannitol | PS80 | P188 | |
|---|---|---|---|---|---|---|
| Silicone oil | 0 | |||||
| Glass | 11.60 | 0 | ||||
| Water | 18.52 | 17.58 | 0 | |||
| Mannitol | 18.12 | 19.25 | 4.07 | 0 | ||
| PS80 | 4.25 | 8.57 | 11.94 | 12.66 | 0 | |
| P188 | 7.89 | 11.84 | 8.30 | 6.20 | N/A | 0 |
| Acetic acid | 11.46 | 5.61 | 12.09 | 13.73 | 5.48 | 7.96 |
| Histidine | 15.52 | 14.47 | 5.40 | 8.16 | 8.63 | 8.72 |
| Citric acid | 23.21 | 17.86 | 10.75 | 14.84 | 15.99 | 17.28 |