TABLE I

Hansen Solubility Parameters for Key Excipients, Silicone Oil, Water, and Borosilicate Glass

δd (MPa1/2)δp (MPa1/2)δh (MPa1/2)
Acetic acid14.58.013.5
Histidine18.611.817.03
Citric acid17.611.3625.98
Mannitol16.1524.5314.56
PS80 (combined)16.76.59.4
PS80 (hydrophobic part)16.30.71.7
PS80 (hydrophilic part)16.87.310.6
P188 (combined)17.4910.238.74
P188 (hydrophobic part)20.963.197.54
P188 (hydrophilic part)16.6116.839.17
Silicone oil 114.01.01.0
Silicone oil 217.04.04.0
Borosilicate glass13.253.0312.79
Water18.117.116.9