Hold-up Volumes of Sorbitol-Based Aqueous Solutions, in Vial and Withdrawal Syringe. The Average and Standard Deviation Values Were Calculated from a Minimum of 10 Measurements (5 Fill Volumes Tested at Least in Duplicate)
| Viscosity at 20°C (η, mPa·s) | Hold-up Volume (µL) | Vial Format | |||
|---|---|---|---|---|---|
| 2R | 6R | 10R | 20R | ||
| 1.04 | Vial (VHUv) | 115 ± 25 | 207 ± 45 | 193 ± 30 | 113 ± 62 |
| Syringe (VHUs) | 62 ± 16 | 132 ± 59 | 124 ± 81 | 129 ± 39 | |
| Vial + Syringe (VHU) | 177 ± 34 | 338 ± 87 | 317 ± 73 | 242 ± 74 | |
| 2.90 | Vial (VHUv) | 115 ± 27 | 205 ± 29 | 250 ± 25 | 185 ± 59 |
| Syringe (VHUs) | 89 ± 36 | 66 ± 28 | 125 ± 14 | 138 ± 68 | |
| Vial + Syringe (VHU) | 204 ± 52 | 271 ± 31 | 375 ± 32 | 323 ± 72 | |
| 4.13 | Vial (VHUv) | 122 ± 18 | 203 ± 29 | 257 ± 28 | 162 ± 36 |
| Syringe (VHUs) | 89 ± 48 | 65 ± 30 | 67 ± 24 | 159 ± 32 | |
| Vial + Syringe (VHU) | 211 ± 37 | 268 ± 53 | 324 ± 32 | 321 ± 50 | |
| 6.40 | Vial (VHUv) | 140 ± 24 | 221 ± 39 | 292 ± 34 | 154 ± 40 |
| Syringe (VHUs) | 105 ± 30 | 115 ± 43 | 100 ± 44 | 77 ± 22 | |
| Vial + Syringe (VHU) | 245 ± 39 | 336 ± 50 | 393 ± 65 | 231 ± 52 | |
| 10.58 | Vial (VHUv) | 146 ± 30 | 313 ± 65 | 283 ± 17 | 197 ± 72 |
| Syringe (VHUs) | 61 ± 27 | 98 ± 12 | 111 ± 48 | 91 ± 29 | |
| Vial + Syringe (VHU) | 206 ± 28 | 411 ± 59 | 394 ± 41 | 288 ± 73 | |
| 20.51 | Vial (VHUv) | 168 ± 36 | 279 ± 41 | 374 ± 61 | 295 ± 88 |
| Syringe (VHUs) | 99 ± 25 | 86 ± 10 | 123 ± 36 | 128 ± 31 | |
| Vial + Syringe (VHU) | 267 ± 42 | 366 ± 39 | 497 ± 54 | 423 ± 85 | |
| 43.39 | Vial (VHUv) | 184 ± 26 | 319 ± 53 | 361 ± 41 | 440 ± 114 |
| Syringe (VHUs) | 112 ± 26 | 92 ± 15 | 81 ± 23 | 170 ± 33 | |
| Vial + Syringe (VHU) | 295 ± 41 | 411 ± 54 | 442 ± 46 | 610 ± 107 | |