General Reference: Analytical Methods in Cleaning Validation (10)
| Method | Specificity | Able to Detect | Cost | |||
|---|---|---|---|---|---|---|
| API | Excipients | Cleaning agents | Waste/Biopharmaceuticals API | *: LOW*****: HIGH | ||
| HPLC | yes | yes | yes | yes | **** | |
| TLC | yes | yes | yes | ** | ||
| TOC | yes | yes | yes | yes | yes | *** |
| Spectrophotometry | yes | yes | yes | yes | ** | |
| pH | No | yes | * | |||
| Conductivity | No | yes | * | |||
| Gravimetric | No | yes | yes | * | ||
| ELISA | yes (BIO) | yes | ***** | |||
| Electrophoresis | yes (BIO) | yes | ||||