Solubilizing, Wetting, Suspending, Emulsifying, or Thickening Agents
| Excipient | Frequency | Range | Example |
|---|---|---|---|
| Acacia | 2 | 7% | Tuberculin Old Test® (Lederle) 7% |
| Aluminum monostearate | 1 | 2% | Solganal Injection® (Schering) 2% |
| Carboxy methyl cellulose | 4 | 0.50–0.55% | Bicillin® (Wyeth-Ayerst) 0.55% |
| Caboxy methyl cellulose, sodium (Crosscarmellose sodium) | 21 | 0.15–3.0% | Nutropin Depot® (Genentech) 3% |
| Cremophor EL* | 3 | 50–65% w/v | Sandimmune® (Sandoz) 65% w/v |
| Cyclodextrin, gamma | 1 | 5.0% | Cardiotec (BMS) |
| Cyclodextrin, alpha | 1 | 0.14% | Edex (Schwartz) |
| Hydroxypropyl-beta-cyclodextrin | 2 | 16–40% | Sporanox (Janssen) |
| Sulfobutylether cyclodextrin sodium | 3 | 15–29.4% | Geodon (Pfizer) |
| Desoxycholate sodium | 1 | 0.4% w/v | Fungizone® (Bristol Myers) 0.41% w/v |
| Egg yolk phospholipid | 3 | 1.2% | Cleviprex® (The Medicines Co.) |
| Gelatin, hydrolzyed | 1 | 16% w/v | Cortone® (Merck) 16% w/v |
| Lecithin | 8 | 0.4–1.2% w/v | Diprivan® (Zeneca) 1.2% w/v |
| Polyoxyethylated fatty acid | 1 | 7% w/v | AquaMephyton® (Merck) 7% w/v |
| Polysorbate 80 (Tween 80) | 72 | 0.001–100% | Aquasol A parenteral® (Astra) 12% Taxotere® (Aventis) 100% |
| Polysorbate 20 (Tween 20) | 22 | 0.001–0.4% | Calcijex® (Abbott) 0.4% w/v |
| PEG 40 castor oil** | 1 | 11.5% v/v | Monistat® (Janssen) 11.5% v/v |
| PEG 60 castor oil*** | 1 | 20% w/v | Prograf® (Fujisawa) 20% w/v |
| Poloxamer 188 (Pluronic F68) | 5 | 0.005–0.3% | Norditropin (NovoNordisk) 0.3% |
| Povidone (Polyvinyl pyrrolidone, Crosspovidone) | 7 | 0.5–0.6% w/v | Bicillin® (Wyeth-Ayerst) 0.6% w/v |
| Sodium dodecyl sulfate (Na lauryl sulfate) | 1 | 0.018% w/v | Proleukin® (Cetus) 0.018% w/v |
| Sorbitol | 3 | 25–50% | Aristrospan® (Fujisawa) 50% v/v |
| Triton X-100 (Octoxynol-9) | 1 | 0.0085% w/v | Fluarix® (GSK) |
↵* Cremophor EL, Etocas 35, polyethoxylated castor oil, polyoxyethylene 35 castor oil.
↵** PEG 40 castor oil, polyoxyl 40 castor oil, castor oil POE-40, Croduret 40, polyoxyethylene 40 castoroil, Protachem CA-40.
↵*** PEG 60 hydrogenated castor oil; Cremophor RH 60, hydrogenated castor oil POE-60, Protachem CAH-60.