Excipients Listed in the FDA Inactive Ingredient Guide*
| Excipient | Route/Dosage Form | Concentration |
|---|---|---|
| 1,2-dimyristoyl-sn-glycero-3-(phospho-s-(1-glycerol) | IV (infusion); suspension, injection | 0.15 |
| 1,2-Dioleoyl-sn-glycero-3-phosphocholine | Epidural; injection, suspension, liposomal | 0.42 |
| 1,2-Dipalmitoyl-sn-glycero-3-(phospho-rac-(1-glycerol) | Epidural; injection, suspension, liposomal | 0.09 |
| 1,2-Distearoyl-sn-glycero-3-(phospho-rac-(1-glycerol) | Intravenous; injection, powder, lyophilized, for liposomal suspension | 8.4 |
| 1,2-Distearoyl-sn-glycero-3-phosphocholine | Intravenous; solution, liposome, injection | 2.8 |
| 1-Methyl-2-pyrrolidinone | Subcutaneous; injection | 25.85 |
| Acetic acid | Intravenous; injection | 12.75 |
| Acetic anhydride | Intravenous; injection | |
| Acetone sodium bisulfite | AN,CNBLK intrathecal; injection | |
| Acetylated monoglycerides | Intravenous; injection | |
| Acetyltryptophan | Intravenous; injection | 0.02 |
| Activated charcoal | Intramuscular; injectable | 0.3 |
| Adipic acid | Intramuscular; injection | 1 |
| Alanine | IV (infusion); injection | 77 |
| Albumin aggregated | Intravenous; injection | 0.15 |
| Albumin colloidal | Intravenous; powder, for injection solution | 0.1 |
| Albumin human | IV (infusion); powder, for injection solution, lyophilized | 80 |
| Albumin microshere human serum | Intravenous; injection | 0.5 |
| Alcohol | Intravenous; injection | 49 |
| Alcohol, dehydrated | IV (infusion); injection | 80 |
| Alcohol, denatured | Intravenous; injection | |
| Alcohol, diluted | IM–IV; injection | 10 |
| Alfadex | Intracavitary; powder, for injection solution, lyophilized | 0.12 |
| Alpha-tocopherol, DL- | Intravenous; solution, concentrate | 0.07 |
| Ammonium acetate | Intramuscular; injection | 0.8 |
| Ammonium hydroxide | Intravenous; injection | 0.21 |
| Ammonium sulfate | Intravenous; injection, suspension, liposomal | 0.2 |
| Anhydrous citric acid | Intravenous; powder, for injection solution, lyophilized | 42.18 |
| Anhydrous lactose | Intravenous; powder, for injection solution, lyophilized | 28.75 |
| Arginine | IV (infusion); injection | 88 |
| Ascorbic acid | Intravenous; injection | 62.5 |
| Aspartic acid | IV (infusion); injection | 0.68 |
| Benzalkonium chloride | Intramuscular; injection | |
| Benzenesulfonic acid | Intravenous; injection | |
| Benzenesulfonic acid | IV (infusion); injection | |
| Benzethonium chloride | Intravenous; powder, for injection solution | 0.05 |
| Benzoic acid | IM–IV; injection | 5 |
| Benzyl alcohol | Intramuscular; injection | 10.96 |
| Benzyl benzoate | Intramuscular; injection | 46 |
| Benzyl chloride | Intravenous; injection | 1.00E-03 |
| Bibapcitide | Intravenous; injection | 0.01 |
| Boric acid | Intravenous; solution, injection | 0.31 |
| Brocrinat | IV (infusion); injection | |
| Butylated hydroxyanisole | Intramuscular; injection | 0.03 |
| Butylated hydroxytoluene | Intramuscular; injection | 0.03 |
| Butylated hydroxytoluene | Intravenous; powder, for injection solution, lyophilized | 1.50E-03 |
| Butylparaben | Intramuscular; injection | |
| Calcium | Intramuscular; injection | 1.20E-03 |
| Calcium chloride | IM–IV; injection | 4 |
| Calcium gluceptate | Intravenous; injection | 5 |
| Calcium hydroxide | Intravenous; injection | 0.37 |
| Caldiamide sodium | Intravenous; solution, injection | 1.2 |
| Calteridol calcium | Intravenous; injection | 0.02 |
| Captisol | Intravenous; injection | 67.5 |
| Carbon dioxide | IM–IV; injection | |
| Carboxymethylcellulose | Intramuscular; injection | 0.9 |
| Carboxymethylcellulose sodium | Intramuscular; injection | 3 |
| Castor oil | Intramuscular; injection | |
| Cellulose, microcrystalline | Intravenous; injection | 14.9 |
| Chlorobutanol | IV (infusion); injection | 0.6 |
| Chlorobutanol hemihydrate | Intramuscular; injection | 0.52 |
| Chlorobutanol, anhydrous | Intramuscular; injection | 0.52 |
| Cholesterol | Intravenous; solution, liposome, injection | 0.68 |
| Citrate | Intravenous; injectable | 0.72 |
| Citric acid | Intravenous; injectable | 41.36 |
| Citric acid monohydrate | Intravenous; injection | 52.5 |
| Citric acid, hydrous | Intravenous; injection | 10.5 |
| Corn oil | Intramuscular; injection | |
| Cottonseed oil | Intramuscular; injection | 87.46 |
| Creatine | Intramuscular; injection | |
| Creatinine | IM–IV; injection | 0.8 |
| Cresol | Subcutaneous; injection | |
| Croscarmellose sodium | Intramuscular; injection | 1 |
| Crospovidone | Intramuscular; injection | 0.02 |
| Cysteine | Intravenous; powder, for injection solution, lyophilized | 2.6 |
| Cysteine hydrochloride | IV (infusion); injection | 2 |
| Cysteine hydrochloride, anhydrous | Intradiscal; powder, for injection solution | |
| Deoxycholic acid | IV (infusion); powder, for injection solution | |
| Dextran | Intravenous; liquid, concentrate, injection | |
| Dextran 40 | Intravenous; powder, for injection solution, lyophilized | 30 |
| Dextrose | Intravenous; injection | 30 |
| Dextrose monohydrate | Intravenous; solution, injection | 5 |
| Dextrose solution | IV (infusion); powder, for injection solution | 5 |
| Dextrose, anhydrous | Spinal; injection | 8.25 |
| Diatrizoic acid | Intramuscular; injection | 59.7 |
| Diethanolamine | IV (infusion); injection | 1.5 |
| Dimethicone 360 | Intravenous; injectable | |
| Dimethyl sulfoxide | IV (infusion); powder, for injection suspension, lyophilized | |
| Dimyristoyl lecithin | Intravenous; powder, for injection solution, lyophilized | 7.05 |
| Disodium sulfosalicylate | IV (infusion); powder, for injection solution, lyophilized | 0.03 |
| Disofenin | IV (infusion); injection | 2 |
| Docusate sodium | Intramuscular; injection | 0.01 |
| Edetate calcium disodium | Intravenous; injection | 0.48 |
| Edetate disodium | Intravenous; injection | 10 |
| Edetate disodium anhydrous | Intravenous; injection | 0.02 |
| Edetate sodium | IV (infusion); solution, injection | 0.04 |
| Edetic acid | Submucosal; solution, injection | 0.05 |
| Egg phospholipids | IV (infusion); injection | 1.8 |
| Ethanolamine hydrochloride | Intravenous; injection | 0.15 |
| Ethyl acetate | Intramuscular; injection | |
| Ethylenediamine | IV (infusion); injection | 0.39 |
| Exametazime | Intravenous; injection | |
| Fampridine | Intravenous; injection | |
| Ferric chloride | Intravenous; injection | 6.05 |
| Fructose | IV (infusion); powder, for injection solution, lyophilized | 5 |
| Gadolinium oxide | Intravenous; injection | |
| Gamma-cyclodextrin | Intravenous; injection | 5 |
| Gelatin | IM–SC; injection | 16 |
| Gentisic acid | Intravenous; injection | 0.05 |
| Gentisic acid ethanolamide | IV (infusion); injection | 2 |
| Gluceptate sodium | Intravenous; powder, for injection solution | 20 |
| Gluceptate sodium dihydrate | Intravenous; injection | 7.5 |
| Gluconolactone | IM–IV; injection | |
| Glucuronic acid | Intravenous; injection | |
| Glutathione | Intramuscular; injection, sustained action | 0.5 |
| Glycerin | Subcutaneous; injection | 32.5 |
| Glycine | IV (infusion); solution, injection | 42 |
| Glycine hydrochloride | Subcutaneous; solution, injection | 0.01 |
| Glycocholic acid | Intravenous; powder, for injection solution, lyophilized | 14 |
| Guanidine hydrochloride | Intravenous; injection | 0.25 |
| Hetastarch | Intravenous; powder, for injection solution | 7.36 |
| Histidine | IV (infusion); injection | 37.2 |
| Hyaluronate sodium | Intra-articular; injectable | 2.3 |
| Hydrochloric acid | Intravenous; powder, for injection solution, lyophilized | 16 |
| Hydrochloric acid, diluted | AN,infiltration; injection | 1.36 |
| Hydroxyethylpiperazine ethane sulfonic acid | Intravenous; injection | |
| Hydroxypropyl-β-cyclodextrin | IV (infusion); injection | 0.4 |
| Insulin beef | Subcutaneous; injection | 0.1 |
| Insulin pork | Subcutaneous; injection | 0.1 |
| Iodine | Intravenous; injection | |
| Iodoxamic acid | Intravenous; injection | 31 |
| Iofetamine hydrochloride | Intravenous; injection | |
| Isoleucine | IV (infusion); injection | 90 |
| Isopropyl alcohol | Intravenous; injection | |
| Isotonic sodium chloride solution | Intravenous; injection | 0.9 |
| Lactic acid | IV (infusion); injection | 32.2 |
| Lactic acid, DL- | IV (infusion); injection | 2.82 |
| Lactic acid, L- | Intravenous; injectable | 0.4 |
| Lactobionic acid | IV (infusion); powder, for injection solution | |
| Lactose | Intravenous; injection | 50 |
| Lactose monohydrate | IV (infusion); powder, for injection solution, lyophilized | 90 |
| Lactose, hydrous | Intravenous; powder, for injection solution | 75 |
| Lecithin | Intramuscular; injection | 2.3 |
| Lecithin, egg | Intravenous; injectable | 1.2 |
| Lecithin, hydrogenated soy | Intravenous; injection, powder, lyophilized, for liposomal suspension | 21.3 |
| Lecithin, soybean | Intravenous; powder, for injection solution, lyophilized | 11.25 |
| Leucine | IV (infusion); injection | 52.6 |
| Lidofenin | Intravenous; injection | |
| Lysine | IV (infusion); injection | 61 |
| Lysine acetate | IV (infusion); solution, injection | 31 |
| Magnesium chloride | IV (infusion); injection | 10.2 |
| Magnesium stearate | Implantation; injection | 1.50E-03 |
| Maleic acid | IV (infusion); injectable | 0.01 |
| Mannitol | IV (infusion); powder, for injection solution | 75 |
| Mebrofenin | Intravenous; injection | |
| Medronate disodium | Intravenous; injection | 1 |
| Medronic acid | Intravenous; injection | 2.5 |
| Meglumine | Intramuscular; injection | 15.92 |
| Metacresol | Subcutaneous; solution, injection | 0.52 |
| Metaphosphoric acid | IV (infusion); injection | 0.13 |
| Methanesulfonic acid | IV (infusion); powder, for injection solution, lyophilized | 8.07 |
| Methionine | IV (infusion); injection | 49.2 |
| Methyl boronic acid | Intravenous; injection | 0.2 |
| Methylcellulose | Intra-articular; injection | 0.1 |
| Methylene blue | Intravenous; injection | 1 |
| Methylparaben | Intravenous; injection | 1.8 |
| Myristyl-gamma-picolinium chloride | Intramuscular; injection | 0.01 |
| N-(carbamoyl-methoxy PEG-40)-1,2-distearoyl-cephalin sodium | Intravenous; injection, suspension, liposomal | 0.31 |
| N,N-dimethylacetamide | Intravenous; injection | 1.8 |
| Niacinamide | IM–IV; injection | 2.5 |
| Nioxime | Intravenous; injection | 0.2 |
| Nitric acid | IV (infusion); injection | |
| Nitrogen | Intravenous; injection | |
| Octanoic acid | Intravenous; injection | 0.01 |
| Oxidronate sodium | Intravenous; injection | 0.2 |
| Oxyquinoline | Intravenous; injection | 5.00E-03 |
| Peanut oil | Intramuscular; injection | |
| PEG sorbitan isostearate | Intramuscular; injection | |
| PEG vegetable oil | IM–SC; injection | 7 |
| Pentetate calcium trisodium | Intrathecal; injection | |
| Pentetate pentasodium | Intravenous; injection | 0.5 |
| Pentetic acid | Intravenous; injection | 0.2 |
| Perflutren | Intravenous; injection | |
| Phenol | IM–IV; injection | 1 |
| Phenol, liquefied | IM–IV; injection | 0.5 |
| Phenylalanine | IV (infusion); injection | 52.6 |
| Phenylmercuric nitrate | Intramuscular; powder, for injection solution | |
| Phosphatidyl glycerol, egg | Intravenous; powder, for injection solution, lyophilized | 4.87 |
| Phospholipid | IV (infusion); emulsion, injection | 12 |
| Phospholipid, egg | IV (infusion); injection | 1.2 |
| Phosphoric acid | IV (infusion); injection | 11.5 |
| Poloxamer 188 | Intravenous; injection | 0.6 |
| Polyethylene glycol 200 | Intramuscular; injection | 30 |
| Polyethylene glycol 300 | Intravenous; injection | 65 |
| Polyethylene glycol 3350 | Intra-articular; injection | 3 |
| Polyethylene glycol 400 | IM–IV; injection | 20.3 |
| Polyethylene glycol 4000 | Intramuscular; injection | 3 |
| Polyethylene glycol 600 | Intravenous; injection | 5 |
| Polyglactin | Intramuscular; injection, microspheres | 56.64 |
| Polylactide | Intramuscular; powder, for injection suspension, lyophilized | 26.48 |
| Polyoxyethylene fatty acid esters | IM–SC; injection | 7 |
| Polyoxyl 35 castor oil | IV (infusion); injection | 65 |
| Polyoxyl 40 castor oil | IM–SC; injection | 7 |
| Polyoxyl 60 castor oil | IV (infusion); injection | 20 |
| Polypropylene glycol | IM–IV; injectable | 40 |
| Polysiloxane | Intravenous; injectable | |
| Polysorbate 20 | IV (infusion); injection | 2.4 |
| Polysorbate 40 | IM–IV; injection | |
| Polysorbate 80 | Intramuscular; injection | 12 |
| Polyvinyl alcohol | Intramuscular; injection, microspheres | |
| Potassium bisulfite | Intravenous; injection | |
| Potassium chloride | Intravenous; solution, injection | 0.38 |
| Potassium hydroxide | Intravenous; injection | |
| Potassium metabisulfite | IV (infusion); solution, injection | 5 |
| Potassium phosphate, dibasic | IV (infusion); injection | 55.2 |
| Potassium phosphate, monobasic | Nerve block; injection | 2.72 |
| Povidone K17 | Subcutaneous; suspension, injection | 0.5 |
| Proline | IV (infusion); injection | 80 |
| Propyl gallate | Intramuscular; injection | |
| Propylene glycol | IM–IV; injection | 82.04 |
| Propylparaben | IM–IV–SC; injection | 20 |
| Protamine sulfate | Intradermal; injection | 0.12 |
| Saccharin sodium | IM–IV; injection | 0.09 |
| Saccharin sodium anhydrous | IM–IV; injection | 0.09 |
| Serine | IV (infusion); injection | 50 |
| Sesame oil | Intramuscular; injection | 70 |
| Silicone | IM–IV; injection | |
| Simethicone | IM–IV; powder, for injection solution | |
| Sodium acetate | IV (infusion); injection | 59.4 |
| Sodium acetate anhydrous | IV (infusion); injection | 6.25 |
| Sodium ascorbate | Intravenous; injection | 1 |
| Sodium benzoate | IM–IV; injection | 10 |
| Sodium bicarbonate | IV (infusion); injection | 83 |
| Sodium bisulfate | IM–IV; injection | 0.32 |
| Sodium bisulfite | IV (infusion); injection | 10 |
| Sodium carbonate | IM–IV; powder, for injection solution | 70.8 |
| Sodium carbonate decahydrate | Intravenous; injection | 12.42 |
| Sodium carbonate monohydrate | Intracardiac; injection | |
| Sodium chlorate | IV (infusion); injection | 15.4 |
| Sodium chloride | Intravenous; injection | 90 |
| Sodium chloride injection | Intramuscular; injection | |
| Sodium chloride injection, bacteriostatic | Intravenous; injection | |
| Sodium cholesteryl sulfate | IV (infusion); powder, for injection suspension, lyophilized | 5.67 |
| Sodium citrate | IM–IV; injection | 40 |
| Sodium cysteinate hydrochloride | Intradiscal; powder, for injection solution | |
| Sodium desoxycholate | IV (infusion); powder, for injection solution | 4.1 |
| Sodium dithionite | Intravenous; injection | 3 |
| Sodium formaldehyde sulfoxylate | Intramuscular; injection | 0.2 |
| Sodium gluconate | Intravenous; injection | 2.3 |
| Sodium hydroxide | IV (infusion); injection | 13 |
| Sodium hypochlorite | IV (infusion); injection | 1 |
| Sodium iodide | Intravenous; powder, for injection solution | 5 |
| Sodium lactate | Intravenous; powder, for injection solution, lyophilized | 1.87 |
| Sodium lactate, L- | IM–IV–SC; injection | 0.18 |
| Sodium metabisulfite | IM–IV; injection | 27.5 |
| Sodium phosphate | IV (infusion); injection | 79 |
| Sodium phosphate dihydrate | Subcutaneous; injection | 0.24 |
| Sodium phosphate, dibasic | IM–IV; injectable | 1.74 |
| Sodium phosphate, dibasic anhydrous | IM–IV; injection | 13.92 |
| Sodium phosphate, dibasic, dihydrate | Intravenous; solution, injection | 1.09 |
| Sodium phosphate, dibasic, heptahydrate | Intravenous; injection | 43 |
| Sodium phosphate, monobasic | IM–IV; injection | 1.47 |
| Sodium phosphate, monobasic anhydrous | Subcutaneous; injection | 3.31 |
| Sodium phosphate, monobasic, dihydrate | Intravenous; injection | 0.76 |
| Sodium phosphate, monobasic, monohydrate | Intravenous; injection | 6.21 |
| Sodium pyrophosphate | Intravenous; injection | 1.2 |
| Sodium succinate | Intravenous; injection, powder, lyophilized, for liposomal suspension | 2.7 |
| Sodium sulfate | IM–IV; injection | |
| Sodium sulfate anhydrous | Intramuscular; injection | |
| Sodium sulfite | IM–IV; injection | 0.2 |
| Sodium tartrate | Intramuscular; injection | 1.41 |
| Sodium thioglycolate | Subcutaneous; injection | 0.66 |
| Sodium thiomalate | IM–IV; injection | |
| Sodium thiosulfate | Intravenous; solution | |
| Sodium thiosulfate anhydrous | Intravenous; solution | 0.19 |
| Sodium trimetaphosphate | Intravenous; powder, for injection solution | |
| Sorbitan monopalmitate | Intramuscular; injection | |
| Sorbitol | Intrasynovial; injection | 45 |
| Sorbitol solution | Intramuscular; injection | 25 |
| Soybean oil | Intravenous; injectable | 10 |
| Stannous chloride | Intravenous; injection | 0.34 |
| Stannous chloride anhydrous | Intravenous; injection | 5.00E-03 |
| Stannous fluoride | Intravenous; injection | 0.07 |
| Stannous tartrate | Intravenous; injection | 8.00E-03 |
| Starch | Intramuscular; injection | 0.6 |
| Succimer | Intravenous; injection | |
| Succinic acid | IM–IV; injection | |
| Sucrose | Intravenous; injection, powder, lyophilized, for liposomal suspension | 90 |
| Sulfobutylether β-cyclodextrin | Intramuscular; powder, for injection solution, lyophilized, with additives | 44.14 |
| Sulfur dioxide | IV (infusion); solution, injection | 0.15 |
| Sulfuric acid | IM–IV; injection | 56.6 |
| Sulfurous acid | Intramuscular; injection | |
| Tartaric acid | Intramuscular; injection | 0.35 |
| Tartaric acid, DL- | IM–IV; injection | |
| Tetrakis(1-isocyano-2-methoxy-2-methyl-propane)-copper(I) tetrafluoroborate | Intravenous; injection | 0.1 |
| Tetrofosmin | IV (infusion); powder, for injection solution, lyophilized | 0.02 |
| Theophylline | IV (infusion); injection | |
| Thimerosal | Subcutaneous; injection | 0.01 |
| Thioglycerol | Intramuscular; injection | 1 |
| Threonine | IV (infusion); injection | 45 |
| Tin | Intravenous; injection | 8.30E-03 |
| Tricaprylin | Epidural; injection, suspension, liposomal | 0.03 |
| Trifluoroacetic acid | IV (infusion); powder, for injection solution, lyophilized | |
| Triolein | Epidural; injection, suspension, liposomal | 0.01 |
| Trisodium citrate dihydrate | Intravenous; powder, for injection solution, lyophilized | 23.52 |
| Trisodium citrate, anhydrous | IM–IV; injection | 16 |
| Tromethamine | IM–IV; injection, solution | 1.21 |
| Tryptophan | IV (infusion); injection | 15.2 |
| Tyrosine | IV (infusion); injection | 3.4 |
| Urea | Intramuscular; injection | |
| Valine | IV (infusion); injection | 84 |
| Versetamide | Intravenous; injection | 2.54 |
| Zinc | Subcutaneous; suspension, injection | 3.27 |
| Zinc acetate | Subcutaneous; powder, for injection suspension | 0.23 |
| Zinc carbonate | Subcutaneous; powder, for injection suspension | 0.16 |
| Zinc chloride | Intradermal; injection | 0.04 |
| Zinc oxide | Subcutaneous; injection | 0.01 |
↵* Highlighted rows are those excipients that were found in our survey.
IM = intramuscular.
IV = intravenous.
SC = subcutaneous.