Solvents and Co-Solvents
| Excipient | Frequency | Range | Example |
|---|---|---|---|
| Benzyl benzoate | 3 | 20–44.7% w/v | Delestrogen® 40 mg/mL (Bristol Myers) 44.7% w/v |
| Castor oil | 2 | 11.50% | Delestrogen® 40 mg/mL (Bristol Myers) |
| Cottonseed oil | 1 | 73.6%–87.4% w/v | Depo®Testosterone (Pfizer) 73.6% w/v |
| N,N dimethylacetamide | 2 | 6–33% w/v | Busulfex® (Orphan Medical) 33% |
| Ethanol/ethanol dehydrated | 34 | 0.6–100% | Prograf® (Fujisawa) 80% v/v, Alprostadil (Bedford Lab) 100% |
| Glycerin (glycerol) | 17 | 1.6–70% w/v | Multitest CMI® (Pasteur Merieux) 70% w/v |
| N-methyl-2-pyrrolidone | 1 | * | Eligrad 7.5 mg (Sanofi) |
| Peanut oil | 1 | * | Bal in Oil® (Becton Dickinson) |
| Polyethylene glycol | |||
| PEG** | 5 | 0.15–50% | Secobarbital sodium (Wyeth-Ayerst) 50% |
| PEG 300 | 4 | 50–65% | VePesid® (Bristol Myers) 65% w/v |
| PEG 400 | 4 | 11.2–67% v/v | Busulfex® (Orphan Medical) 67% |
| PEG 600 | 1 | 5% w/v | Persantine® (Dupont-Merck) |
| PEG 3350 | 4 | 0.3–3% | Depo-Medrol® (Upjohn) 2.95% w/v |
| PEG 4000 | 1 | 0.3–3% | Invega Sustenna® (Janssen) |
| Poppyseed oil | 1 | * | Ethiodol® (Savage) |
| Propylene glycol | 32 | 0.0025–80% | Ativan® (Wyeth-Ayerst) 80% |
| Safflower oil | 2 | 5–10% | Liposyn II® (Abbott) 10% |
| Seasme oil | 7 | 100% | Solganal Injection® (Schering) |
| Soybean oil | 1 | 10% w/v | Diprivan Injection (Zeneca) |
| Vegetable oil | 2 | * | Virilon IM Injection® (Star Pharmaceuticals) |