Actual Measurement of the Increasing Moisture Content inside the Lyophilized Vials
| Stoppers | A: Early Stage | B: Late Stage | c: Time of the Stage Change | ||
|---|---|---|---|---|---|
| Drying Time | The Increased Amounts of the Moisture Content Inside the Lyophilized Vials from Time Zero to 93 Days [mg/vial·day] | Drying Time | The Increased Amounts of the Moisture Content Inside the Lyophilized Vials from 91 to 364 Days [mg/vial·day] | ||
| HM stopper | 1 h 50 min | 4.62 × 10−3 | 2 h | 0.73 × 10−3 | ∼91 days |
| 3 h 10 min | 4.09 × 10−3 | ||||
| 5 h 20 min | 3.33 × 10−3 | ||||
| 11 h 20 min | 2.04 × 10−3 | 24 h | 0.44 × 10−3 | ||
| 25 h 30 min | 1.40 × 10−3 | ||||
| LM stopper | 2 h | 1.32 × 10−3 | ∼28 days | ||
| 24 h | 1.36 × 10−3 | ||||