TABLE III

Analysis of Variance for Robustness Evaluation

Organism	One-Sided Lower 95.5% Confidence Limit Log₁₀(MPN)^a	Site Variance	P > \|Z\|^b
Clostridium sporogenes	−0.050	0.0093	0.2522
Propionibacterium acnes	0.415	0.0857	0.1780
Escherichia coli	0.092	0.0000	1.0000
Pseudomonas aeruginosa	0.771	0.0218	0.2366
Staphylococcus aureus	0.264	0.0138	0.2227
Bacillus subtilis	0.308	0.0054	0.3167
Aspergillus niger	0.490	0.0014	0.4544
Candida albicans	0.438	0.0270	0.2392

↵a The confidence coefficient selection reflects a 0.5% adjustment for interim analysis. The lower confidence limits are slightly different than those presented in Table II because the standard errors were estimated differently in the robustness model.
↵b P-value for the test whether the site-to-site variance component is significantly different from zero. All are greater than 0.05, indicating that none can be declared significantly different from zero.