TABLE II

Effect of Irradiation and Nanofiltration on Reproducibility of OOS Results

SampleTreatmentResult
Bioreactor sample previously testing OOSUntreatedNegative
Gamma-irradiatedPositive*
NanofilteredNegative
Medium sample previously testing OOSUntreatedNegative
Gamma-irradiatedNegative
NanofilteredNegative
  • * Atypical structures (foci artifact) observed.