Relative Contribution of Various Parameters on Injection Time
| Parameter | Example Variability | Measured Range | Max. % Variability in Force/Time | Variability in Injection Time (Target 10 s) |
|---|---|---|---|---|
| Friction force | NA | 1.8075 ± 0.3762 N | ±2.5% | - |
| Barrel ID (2rb) | 6.35 ± 0.10 mm | 6.28–6.43 mm | ±4.0% | ±0.4 s |
| Needle (27 G) diameter (2rn) | 0.210 ± 0.019 mm | +5.0%/−1.9% | +20.0%/−7.5% | +2.0 s/−0.75 s |
| Product concentration | ±10% | ±30% (viscosity) | ±30.0% | ±3.0 s |
| Temperature | Target ±2 °C | ±10% (viscosity) | ±10.0% | ±1.0 s |
| Spring load | 21.58 N + 10–15% | 21.06 ± 0.61 N | ±15.0% | ±1.5 s |
| Worst case scenario (accumulation of all errors) | ∼80.0% | 10.0 ± ∼8.0 s |