Factors and Set Points Examined by an Amgen DOE Study of Low-pH Inactivation of X-MuLV. The DoE Used a Fractional Factorial, D-Optimal Design
| Factor | Values |
|---|---|
| pH | 3.6, 3.7, 3.8 |
| Temperature (°C) | 15, 18, 21 |
| Pre-titration acetate (mM) | 25, 62.5, 100 |
| Acid titrant | formic, acetic, phosphoric |