Amgen In-House Database, Expanding on Data Presented at the 2009 Symposium. The table reveals >4 log10 MuLV clearance with SO3−-based CEX at pH 5.0. For additional information see references 1, 2.
| Operating pH | Molecule | Log Reduction Value (LRV) | |||
|---|---|---|---|---|---|
| xMuLV | MMV | PRV | Reo-3 | ||
| 5.0 | mAb 1 | ≥5.4, ≥3.8 | 1.8, 1,3 | ≥5.3, ≥5.6 | 2.8, 1.8 |
| mAb 2 | ≥4.4, ≥4.3 | 1.8, <1 | ≥5.1 | ≥4.8 | |
| mAb 3 | ≥5.0 | 1.1 | ≥4.5 | ≥6.2 | |
| mAb 4 | ≥5.8, ≥6.3 | 2.9, 1.5 | |||
| mAb 5 | 6.4, 5.0 | <1.0 | |||
| mAb 6 | 5.6, ≥6.2 | 1.3 | |||
| mAb 7 | 5.4, ≥5.4 | 1.5, 1.4 | |||
| mAb 8 | ≥4.8 | <1 | |||
| mAb 9 | ≥5.1, ≥5.3 | <1 | |||
| mAb 10 | ≥4.1 | 2.5 | |||
| mAb 11 | ≥5.9 | <1 | |||
| mAb 12 | 2.2, 3.9 | <1 | |||
| 5.3 | mAb 13 | ≥5.7, ≥6.0 | 1.4, 1.3 | ||
| 5.5 | mAb 14 | 4.3 | 1.6 | ||
| mAb 15 | 1.8 | 1.3 | |||
| 6.0 | mAb 16 | 1.3, 1.4 | 1.9, 1.6 | 5.0, 5.4 | 2.6, 2.6 |
| mAb 17 | 2.4 | 1.0 | |||
| 6.5 | mAb 18 | 1.1 | <1 | ||