Merck, Sharp and Dohme Study Examining MuLV and MMV Clearance by AEX Membranes Run with Varying Spike Level and Resin Load
| Load - (mAb A) | Clearance Studies Examining Different Virus Spike Procedures | ||
|---|---|---|---|
| Log Reduction Values in Each Fraction | |||
| 0 to 750 g/L | 750 to 1500 g/L | 1500 to 2500 g/L | |
| MuLV 5% spike | >3.8 | >3.9 | 1.3 |
| MuLV 1% spike | >3.0 | 1.8 | 0.9 |
| MuLV 0.5% spike | >3.2 | 3.2 | 1.5 |
| MMV 0.1% standard purity | >4.7 | 2.4 | 0.5 |
| MMV 0.1% higher purity | >4.3 | >4.3 | 0.8 |