Table IV

Example of Experimental Conditions Resulting in Lower LRV for xMuLV as Compared with MMV

Example	Load Titer Log₁₀TCID₅₀/mL	Spike %	Input Titer Log₁₀TCID₅₀/mL	Tox Dil	Output Titer^{^a} Log₁₀TCID₅₀/mL	LRV
MMV	7.50	1.0	5.50	10	≤−0.12	≥5.62
xMuLV	7.00	0.5	4.70	30	≤0.36	≥4.34

↵a Calculations assume a 40 mL large-volume sample and output titer is based on the probability of detecting viruses at low concentrations using the Poisson distribution (1).