Example | Load Titer Log_{10}TCID_{50}/mL | Spike % | Input Titer Log_{10}TCID_{50}/mL | Tox Dil | Output Titer^{a} Log_{10}TCID_{50}/mL | LRV |
---|---|---|---|---|---|---|

MMV | 7.50 | 1.0 | 5.50 | 10 | ≤−0.12 | ≥5.62 |

xMuLV | 7.00 | 0.5 | 4.70 | 30 | ≤0.36 | ≥4.34 |

↵a Calculations assume a 40 mL large-volume sample and output titer is based on the probability of detecting viruses at low concentrations using the Poisson distribution (1).