Effective MuLV inactivation by Triton Detergent across Eight Genentech mAbs (IgG1 and IgG4 Isotypes). Manufacturing conditions for Triton X-100 hold in HCCF are as follows: 0.5 ± 0.2% Triton X-100, ≥20 °C, ≥60 min (target: 0.3% Triton, 20 °C, 60 min).
| mAb | X-MuLV LRV |
|---|---|
| mAb 1 | ≥5.9 |
| mAb 2 | ≥6.3 |
| mAb 3 | ≥6.1 |
| mAb 4 | ≥5.5 |
| mAb 5 | ≥5.0 |
| mAb 6 | 4.6 |
| mAb 7 | ≥5.4 |
| mAb 8 | ≥5.3 |