Extractables with RI Values Lower than 0.1 mg/day
| Extractable | CAS Registry No. | RI, mg/day | Cramer Class | Mutagenicity Alerts |
|---|---|---|---|---|
| 1-Methylethyl benzene | 98-82-8 | 0.070 | 1 | None |
| Acetophenone | 98-86-2 | 0.070c | 1 | None |
| Pyridine | 110-86-1 | 0.070 | 3 | None |
| Benzaldehdye | 100-52-7 | 0.063 | 1 | See footnote e |
| Toluene | 108-88-3 | 0.056d | 1 | None |
| Carbon disulfide | 75-15-0 | 0.053 | 3 | None |
| Pentanal | 110-62-3 | 0.040 | 1 | See footnote e |
| Oleamide | 301-02-0 | 0.035 | 1 | None |
| Tetramethylbutylphenol | 140-66-9 | 0.035 | 1 | None |
| Succinic acid | 110-15-6 | 0.011b | 1 | None |
| 5-Quinolinol | 578-67-6 | 0.006 | 3 | None |
| Oleic acid | 112-80-1 | 0.006a | 1 | None |
| Acrylonitrile | 107-13-1 | 0.001 | 3 | See footnote f |
Notes:
↵a This oleic acid result is based on a TDLO, i.v., in monkeys. An alternate result was based on a TDLO, i.v. in rats, which gave an RI of 7 mg/day.
↵b This succinic acid result is based on a TDLO, oral, in mice. An alternate result was based on a LD50, i.v. in mice which gave an RI of 98 mg/day.
↵c This acetophenone result is based on EPA oral data in humans. An alternate result is based on a LD50, i.p. in mice which gave an RI of 1.4 mg/day. A third result is based on a NOAEL oral study in rats which gave an RI of 30 mg/day.
↵d This toluene result is based on EPA oral data in humans. An alternate result is based on a PDE in humans, which gave an RI of 0.89 mg/day.
e Mutagenicity alerts both in vitro and in silico.
f Mutagenicity alert, in vitro.