Inactivation of XMuLV in HCCF of MAb 1 with Detergents ± Solvent at 20 °C
| Time (h) | Detergent with and without Solvent (LRV of XMuLV) | Detergent (LRV of XMuLV) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1% Poly-sorbate 20 | 1% Poly-sorbate 20 + 0.3% TnBP | 1% Poly-sorbate 80 | 1% Poly-sorbate 80 + 0.3% TnBP | 1% TNBP | 0.5% SafeCare 1000 | 1% SafeCare 1000 | 1.4% Sodium Caprylate | 1% Decyl Glucoside (mixture) | 1% Ecosurf EH-6 | 1% Ecosurf EH-9 | |
| 1 | 1.4 | ≥5.7 | 3.3 | 5.2 | 2.9 | ≥5.1 | ≥5.5 | ≥6.0 | ≥5.1 | ≥4.7 | ≥5.1 |
| 3 | 2.3 | NT | 5.7 | ≥5.5 | 3.1 | 5.7 | ≥5.5 | ≥6.0 | ≥5.1 | ≥4.7 | ≥5.1 |
NT: not tested.