Viscosity and Osmolality of Liquid Formulations Reconstituted from Spray-Dried Powders
| Formulation | Liquid Formulation | Reconstituted Spray-Dried Powder | ||||||
|---|---|---|---|---|---|---|---|---|
| 100 mg/mL | 100 mg/mL | 150 mg/mL | 250 mg/mL | |||||
| Viscosity (cP) | Osmolality (mOsmol/kg) | Viscosity (cP) | Osmolality (mOsmol/kg) | Viscosity (cP) | Osmolality (mOsmol/kg) | Viscosity (cP) | Osmolality (mOsmol/kg) | |
| A-4 | 3.0 ± 0.1 | 201 ± 1 | 2.8 ± 0.2 | 200 ± 1 | 6.7 ± 0.2 | 311 ± 7 | 70.6 ± 6.2 | 626 ± 19 |
| A-5 | 3.4 ± 0.1 | 231 ± 3 | 3.0 ± 0.1 | 224 ± 11 | 7.9 ± 0.7 | 366 ± 10 | 99.1 ± 12.0 | 748 ± 6 |
| A-6 | 3.6 ± 0.1 | 321 ± 3 | 3.7 ± 0.1 | 328 ± 1 | 10.6 ± 0.1 | 531 ± 4 | 207.0 ± 0.2 | 1190 ± 42 |
| B-4 | 3.1 ± 0.0 | 202 ± 1 | 2.6 ± 0.0 | 185 ± 6 | 6.1 ± 0.3 | 288 ± 1 | 49.9 ± 1.2 | 563 ± 8 |
| B-5 | 3.6 ± 0.0 | 255 ± 4 | 2.8 ± 0.2 | 204 ± 3 | 7.1 ± 0.3 | 336 ± 2 | 59.3 ± 1.9 | 635 ± 6 |
| B-6 | 4.0 ± 0.1 | 314 ± 4 | 3.3 ± 0.2 | 303 ± 2 | 10.1 ± 0.2 | 405 ± 3 | 328.7 ± 5.7 | 953 ± 40 |