Table XIV

Extracted Elemental Impurities Reported for Miscellaneous Plastics

Element	Concentration (mg/kg unless noted)	Extraction Details		Comments	Ref.
Element	Concentration (mg/kg unless noted)	Solvent	Conditions	Comments	Ref.
Polystyrene
Al	<0.001	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 19 mg/kg	21
Co	<0.001	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 0.6 mg/kg	21
Cu	0.006	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 16 mg/kg	21
Mg	<0.001	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 23 mg/kg	21
Zn	0.004	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 67 mg/kg	21
Polyethylene Terephthalate
Al	0.001	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 620 mg/kg	21
	0.16 mg/L	pH 6.8 buffer	PET bottle, 40 °C for 23 weeks, 10 mL in 75 mL bottle	Bottles tested^²	23
	0.16 mg/L	0.1% EDTA	PET bottle, 40 °C for 23 weeks, 10 mL in 75 mL bottle	Bottles tested^²	23
Ca	0.24	Low pH (≈3)	Sealed vessel, 55 °C for 5 days, 0.25 g sample/mL solvent	See footnote ^⁵	12
	0.07	High pH (≈9)	Sealed vessel, 55 °C for 5 days, 0.25 g sample/mL solvent	See footnote ^⁵	12
	0.14 mg/L	pH 6.8 buffer	PET bottle, 40 °C for 23 weeks, 10 mL in 75 mL bottle	Bottles tested^²	23
Co	<0.001	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 58 mg/kg	21
Ge	<0.001	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 14 mg/kg	21
Mg	0.003	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 5.9 mg/kg	21
Pb	0.03 mg/L	0.1% EDTA	PET bottle, 40 °C for 23 weeks, 10 mL in 75 mL bottle	Bottles tested^²	23
Sb	0.003	3% acetic acid	Sealed vessel, 40 °C for 10 days, 0.15 g sample/mL solvent	Total pool = 160 mg/kg	21
	343 ng/L	Water	PET bottles; tested samples of bottled water	Median value of 35 products	30
	<0.002	Water, olive oil, 3% acetic acid, ethanol	PET resin, 40 °C for 10 days, 2.8 cm^²/50 mL solvent	Total pool of Sb = 200 mg/kg	44
	89–2570 ng/L	Water	PET bottles with water from several sources (69 brands)	Commercial products tested	51
Ethylene Vinyl Acetate
Al	7.5	High pH (≈9)	Sealed vessel, 121 °C for 1 h, 0.08 g sample/mL solvent	See footnote ^¹	12
	0.70	Ethanol/water	Sealed vessel, 55 °C for 3 days, 0.08 g sample/mL solvent	See footnote ^¹	12
	4 μg/L	Water	Filled bag, ambient temperature, 24 h	Bag size = 3000 mL	50
B	5.2	Low pH (≈3)	Sealed vessel, 121 °C for 1 h, 0.08 g sample/mL solvent	See footnote ^¹	12
B	2.3	Ethanol/water	Sealed vessel, 55 °C for 3 days, 0.08 g sample/mL solvent	See footnote ^¹	12
Ca	1.6	Low pH (≈3)	Sealed vessel, 121 °C for 1 h, 0.08 g sample/mL solvent	See footnote ^¹	12
Ca	1.3	High pH (≈9)
Na	7.5	Low pH (≈3)
S	1.9	High pH (≈9)
Si	1.6	Low pH (≈3)
Cyclic Olefin Copolymer
Al	0.07	pH 2.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Component of prefilled	35
B	0.86	Low pH (≈3)	Sealed vessel, 121 °C for 1 h, 0.08 g sample/mL solvent	See footnote ^⁶	12
B	5.7	High pH (≈9)	Sealed vessel, 121 °C for 1 h, 0.08 g sample/mL solvent	See footnote ^⁶	12
Ba	<0.1	pH 2–12	Sealed vessel, 121 °C for 1 h, 0.07 g sample/mL solvent	Component of prefilled syringe^³	40
Br	0.54	pH 2.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
Br	0.02	pH 9.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
Ca	0.11	High pH (≈9)	Sealed vessel, 121 °C for 1 h, 0.08 g sample/mL solvent	See footnote ^⁶	12
	0.3	pH 2–12	Sealed vessel, 121 °C for 1 h, 0.07 g sample/mL solvent	Component of prefilled syringe^³	40
	0.81	pH 2.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
	1.7	pH 9.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
Fe	0.24	pH 2.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
Mg	<0.1	pH 2–12	Sealed vessel, 121 °C for 1 h, 0.07 g sample/mL solvent	Component of prefilled syringe^³	40
	0.16	pH 2.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
	0.15	pH 9.5
Na	0.96	pH 2.5
Sr	<0.1	pH 2–12	Sealed vessel, 121 °C for 1 h, 0.07 g sample/mL solvent	Component of prefilled syringe^³	40
Zn	0.3	pH 2–12	Sealed vessel, 121 °C for 1 h, 0.07 g sample/mL solvent	Component of prefilled syringe^³	40
	0.07	pH 2.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
	0.03	pH 9.5	Sealed vessel, 121 °C for 1 h, 0.025 g sample/mL solvent	Molded part^⁴	35
Zr	<0.03	pH 2–12	Sealed vessel, 121 °C for 1 h, 0.07 g sample/mL solvent	Component of prefilled syringe^³	40

Notes:
↵1 Elements that were not extracted in reportable levels included Ag, As, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Ge, Li, Mg, Mn, Mo, Ni, Pb, Sb, Se, Sn, Sr, Ti, V, Zn, and Zr.
↵2 Elements that were extracted in reportable levels included Cd, Co, Cr, Cu, Fe, Mg, Mn, Ni, V, and Zn.
↵3 Elements that were not extracted in reportable levels, generally 1 μg/g, included Ag, As, Bi, Co, Cr, Cu, Mo, Ni, Sb, Se, Sn, and V.
↵4 Elements that were not extracted in reportable levels (<0.01 μg/g) included As, Ba, Co, Cr, Cu, K, Mn, Mo, Ni, Pb, Si, Sb, Sr, Ti, and V.
↵5 Elements that were not extracted in reportable levels included Ag, Al, As, B, Ba, Be, Bi, Ca, Cd, Co, Cr, Cu, Fe, Ge, Li, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sb, Se, Si, Sn, Sr, Ti, V, Zr, and Zn.
↵6 Elements that were not extracted in reportable levels included Ag, Al, As, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Ge, Li, Mg, Mn, Mo, Na, Ni, P, Pb, S, Sb, Se, Si, Sn, Sr, Ti, V, Zn, and Zr.