Table V

The Impact of the Accumulative Caustic Exposure Time of the Cycled Resin on Quality Attributes (Residual Protein A and Viral Clearance Levels) and Performance Attributes (DBC and Yield) in a MAb-1 Case Study. Data provided by Al Magill and Daniel Bezila.

Cycle	Caustic Exposure Time (h)	DBC (g/L)	Yield (%)	Residual Protein A (ng/mg)	XMuLV Clearance			MVM Clearance
Cycle	Caustic Exposure Time (h)	DBC (g/L)	Yield (%)	Residual Protein A (ng/mg)	Reused Resin (LRV)	Control Resin (LRV)	Normalized LRV (%)	Reused Resin (LRV)	Control Resin (LRV)	Normalized LRV (%)
1	1	48
2	2		92	7.6
3	3				2.9	3.7	78
4	4							1.9	2.1	90
5	5		97
49	53		90
50	54	45
51	55		89	9.2
52	56				2.7	3.0	90
53	57							2.5	2.5	100
54	59		89
99	107		83
100	108	34
101	109		96	12.5
102	111				3.6	3.3	109
103	112							2.4	2.9	83
104	113		79
124	134		75
125	135	35
126	137		82
127	138				3.3	3.0	110
128	139							2.9	2.9	100
129	140		72
130	141		69
131	142		70
132	143		72
133	144		70
134	145		68
135	146		70
136	147		71
137	148		71
138	150		67
139	151		68
140	152	32
141	153		85	16.6
142	154				2.6	2.7	96
143	155							2.1	2.0	105