Analytical Capabilities for Discovering, Identifying, and Quantifying Extractables and Leachables
| Technique | Commonly Used to Detect | Sensitivity* |
|---|---|---|
| GC/FID** | Volatile organic molecules (boiling point < 300 °C) | ppm |
| GC/MS | Volatile organic molecules (boiling point < 300 °C) | ppb–ppm |
| LC-MS | Organic/inorganic molecules (polar, containing hetero atoms O, N, etc.) | ppb–ppm |
| HPLC | UV-absorbing molecules | ppm |
| ICP-MS | Elemental impurities (W, Al, Si, etc.) | ppb |
| SEC-ELSD | Silicone oil (quantitation/viscosity) | ppm |
| LC-ELSD | Detector for estimating total amount of non-volatile extractables | ppm |
| NMR | Organic molecules | >>ppm |