List of Compounds That Can Potentially Form Covalent Modification of Proteins
| Agents or Mechanisms | Compounds |
|---|---|
| Michael acceptors | (2E,9Z)-Ethyl 12-oxoctadeca-2,9-dienoate 1-((2-Ethylheptyl)oxy)-1-oxopropan-2-yl (1-((2-ethylhexyl)oxy)-1-oxopropan-2-yl) maleate 1-((3-Butyl-4-methylcyclohexa-1,5-dien-1-yl)methoxy)-1-oxopropan-2-yl (1-((4-ethyl-3-methylbenzyl)oxy)-1-oxopropan-2-yl) maleate* 1,6-Hexanedioldiacrylate 13-oxooctadeca-9,11-dienoic acid 1-Hydroxy-2-propyl methacrylate 1-oxo-1-(((2E,5E)-2-((Z)-prop-1-en-1-yl)octa-2,5-dien-1-yl)oxy)propan-2-yl (1-oxo-1-(((E)-2-((Z)-prop-1-en-1-yl)hept-2-en-1-yl)oxy)propan-2-yl) maleate* 2,6 Di(tert-butyl)-4-hydroxy-4-methyl-2,5-cyclohexandien-1-one (BHT-OH)* 2,6-di-tert-butyl-4-methylene-2,5-cyclohexandienone (BHT-quinone-methide)* 2,6-Di-tert-butyl-p-benzoquinone (BHT-quinone)* 2-Hydroxypropyl methacrylate 3-tert-Butyl-4-hydroxyanisole 4-ethyl 1-methyl 2-hexanoylsuccinate 7,9-bis(tert-butyl)-1-oxaspiro[4,5]deca-6,9-diene-2,8-dione (BODDD)* Acrylic Acid Bis(1-((2-ethylhexyl)oxy)-1-oxopropan-2-yl) maleate Isomers Dibutylmaleate Dihexyl maleate (Methyl maleate) Isobornyl methacrylate Methacrylic acid (MAA) Tetraethylene glycol dimethacrylate Tetrahydrofurfuryl methacrylate |
| Schiff base formers | 2,6 Di(tert-butyl)-4-hydroxy-4-methyl-2,5-cyclohexandien-1-one (BHT-OH)* 2,6-di-tert-butyl-4-methylene-2,5-cyclohexandienone (BHT-quinone-methide)* 2,6-Di-tert-butyl-p-benzoquinone (BHT-quinone)* 3,4-Dimethylbenzaldehdye 3,5 Di-tert-butyl-4-hydroxybenzaldehyde (BHT-aldehyde) 3,5,5-Trimethyl-2-cyclohexenone 4-(((1,3-dihydroxypropoxy)(((4Z,6E)-7-hydroxy-4-(hydroxymethyl)-6-methylhepta-4,6-dien-1-yl)oxy)phosphoryl)oxy)-4-hydroxybutanoic acid Benzaldehyde Dodecanamide,N-[3-(dimethyloxidoamino)propyl]Hexanal N,N-bis(2-hydroxyethyl) alkylamine (Atmer 163) N-myristoylethylenediamine/N-stearoylethylenediamine |
| Acylating agents | 1-((3-Butyl-4-methylcyclohexa-1,5-dien-1-yl)methoxy)-1-oxopropan-2-yl (1-((4-ethyl-3-methylbenzyl)oxy)-1-oxopropan-2-yl) maleate* 1,3,5-tris[(3,5-ditert-butyl-4-hydroxyphenyl)methyl]-1,3,5-triazinane-2,4,6-trione 1-oxo-1-(((2E,5E)-2-((Z)-prop-1-en-1-yl)octa-2,5-dien-1-yl)oxy)propan-2-yl (1-oxo-1-(((E)-2-((Z)-prop-1-en-1-yl)hept-2-en-1-yl)oxy)propan-2-yl) maleate* 7,9-bis(tert-butyl)-1-oxaspiro[4,5]deca-6,9-diene-2,8-dione (BODDD)* Decyl (2,6-dimethoxyphenyl) glutarate N-(2-ethyl-1-oxooctyl) alanine Phthalic anhydride |
| Aliphatic nucleophilic substitutions | (2Z, 6E)-1-bromo-6-ethylidene-2-methyldec-2-ene 1-((3-Butyl-4-methylcyclohexa-1,5-dien-1-yl)methoxy)-1-oxopropan-2-yl (1-((4-ethyl-3-methylbenzyl)oxy)-1-oxopropan-2-yl) maleate* 1-oxo-1-(((2E,5E)-2-((Z)-prop-1-en-1-yl)octa-2,5-dien-1-yl)oxy)propan-2-yl (1-oxo-1-(((E)-2-((Z)-prop-1-en-1-yl)hept-2-en-1-yl)oxy)propan-2-yl)* maleate Epoxidized soybean oil Tris (2-chloroethyl) phosphate |
| Aromatic nuceophilic substitutions | Atrazine |
| Transition metals | Chromium Copper Iron Iron oxide Manganese Nickel Tungsten Zinc |
↵* Compounds with multiple mechanisms of interaction.