Table I

CCI Measurements (Helium Leak Rates) of Different Vial Formats Sealed with Bausch & Stroebel or Groninger Capping Equipment

FormatPlunger-Plate Distance (mm)Pre-Compression ForceCapping EquipmentTurntable Rotation Speed (rpm)Helium Leak Rate (mbar L/s)
6 mL serum8.44.0 barBausch & Stroebel–18310–8
6 mL serum8.14.0 barBausch & Stroebel–18310–8
6 mL serum7.74.0 barBausch & Stroebel–18310–8
6 mL serum8.13.4 barBausch & Stroebel–18310–8
6 mL serum8.15.8 barBausch & Stroebel–18310–8
6 mL serum8.14.0 barBausch & Stroebel–53710–8
6 mL serum8.14.0 barBausch & Stroebel14510–8
6 mL serum8.14.0 barBausch & Stroebel38210–8
6 mL serum8.14.0 barBausch & Stroebel77410–8
15 mL lyo8.04.8 barBausch & Stroebel–13610–8
15 mL lyo7.74.8 barBausch & Stroebel–13610–8
15 mL lyo8.03.2 barBausch & Stroebel–13610–8
15 mL lyo8.04.8 barBausch & Stroebel–13610–8
15 mL lyo8.05.8 barBausch & Stroebel–13610–8
15 mL lyo8.04.8 barBausch & Stroebel–52310–8
15 mL lyo8.04.8 barBausch & Stroebel+10810–8
15 mL lyo8.04.8 barBausch & Stroebel+35210–8
15 mL lyo8.04.8 barBausch & Stroebel+74010–8
6 mL serum7.950 NGroninger–14510–8
15 mL lyo7.950 NGroninger–13610–8
20 mL lyo7.950 NGroninger+26310–8