Table I

Marketed Drug Products Stored and Shipped at Low Temperatures (29, 30)

Product NameActive IngredientIndicationTherapeutic ModalityStorage Temperature (°C)PresentationDosage FormExcipients
VarivaxWeakened form of chickenpox virusVaricellaVaccine–15 to –50Glass vialPowderSucrose; hydrolysed gelatin; urea; sodium chloride; monosodium L-glutamate; anhydrous disodium phosphate; potassium dihydrogen phosphate; potassium chloride
ZostavaxAttenuated (Oka-strain) varicella virusZosterVaccine–15 to –50aGlass vialPowderSucrose; hydrolysed porcine gelatin; sodium chloride; monosodium L-glutamate; anhydrous disodium phosphate; potassium dihydrogen phosphate, potassium chloride; sodium hydroxide (pH adjustment)
ProQuadWeakened strains of measles, mumps, rubella (German measles), and varicella virusesMMRVVaccine–15 to –50Glass vialPowderSucrose; hydrolysed gelatin; sodium chloride; sorbitol; monosodium glutamate; sodium phosphate; sodium bicarbonate; potassium phosphate; potassium chloride; Medium 199 with Hanks' Salts; minimum essential medium, Eagle (MEM); neomycin; phenol red; hydrochloric acid (to adjust pH); sodium hydroxide (to adjust pH); urea
M-M-R® IIAttenuated measles, mumps and rubella virusMMRVVaccine+8 to –50bGlass vialPowderSorbitol; sodium phosphate; sucrose; sodium chloride; hydrolyzed gelatine; recombinant human albumin; fetal bovine serum; neomycin; Medium 199 containing SPGA (sucrose, phosphate, glutamate, and recombinant human albumin)
GlyberaAlipogene tiparvovecLPLDViral vector–15 to –25Glass vialSolution for injectionCalcium chloride dihydrate; disodium phosphate anhydrous; magnesium chloride hexahydrate; potassium chloride; potassium dihydrogen phosphate; sodium chloride; sucrose

  • MMRV: Measles, mumps, rubella and varicella.

  • LPLD: Lipoprotein lipase deficiency.

  • ↵a Shipped on dry ice.

  • ↵b Use of dry ice may subject Measles, Mumps, and Rubella Virus Vaccine Live (M-M-R II®) to temperatures colder than –50 °C (1).