Table V
Comparison of MAb and AEX Processing Parameters
Isotype
pI
Operating AEX pH
Operating AEX Condition
Current AEX Resin Properties
MAb Load (g/L)
HCP Reduction
High Molecular Weight Species Reduction
MAb A
IgG1
8.6
7.5
<5 ms/cm
<300
10x
N/A
MAb B
IgG4
6.7
7.2
<6 ms/cm
<165
*
3x
2.5x
↵
*
Challenging impurity removal.