Viral Clearance on New and Cycled (>54) AEX Chromatography Media
| Step | Log10 PFU (by plaque assay) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| X-MuLV | PRV | PPV | Reo-3 | |||||||||
| Run 1 | Run 2 | Cycled | Run 1 | Run 2 | Cycled | Run 1 | Run 2 | Cycled | Run 1 | Run 2 | Cycled | |
| Load | 6.86 | 6.82 | 6.51 | 7.04 | 6.86 | 6.70 | 6.46 | 6.36 | 5.57 | 6.47 | 6.25 | 7.12 |
| Product | <1.74 | <1.73 | <1.66 | <0.96 | <0.95 | 1.78 | 3.55 | 3.53 | 3.07 | <0.94 | <0.95 | <0.96 |
| Cleaning | <2.51 | <2.51 | <2.36 | <1.50 | <1.50 | <2.40 | <1.99 | <1.99 | <2.01 | <1.51 | <1.51 | <2.37 |
| Storage | <1.20 | <2.20 | <1.19 | <1.20 | <1.19 | <1.22 | <1.64 | <1.69 | <1.68 | <1.22 | <1.19 | <1.21 |
| LRV | >5.12 | >5.09 | >4.85 | >6.08 | >5.91 | 4.92 | 2.91 | 2.83 | 2.50 | >5.53 | >5.30 | >6.16 |