XMuLV Low pH Virus Inactivation at 15–26 °C
| mAb | pH | Buffer | Protein Conc. (g/L) | Titrant | Time for No Detected Virus (min) | Step LRF (log10) |
|---|---|---|---|---|---|---|
| 6 | 3.70, 3.71 | 100 mM Gly | 7.0–8.1 | Acetic Acid | 5 | ≥6.6 - ≥6.9 |
| 8 | 3.74, 3.76 | 50 mM Gly | 14.3 | HCl | 15 | ≥5.7 - ≥6.2 |
| 9 | 3.80, 3.81 | 75m M Ace | 5–6 | Acetic Acid | 5 | >4.17, >4.18 |
| 7 | 3.84 | 100 mM Gly, 200 mM Ace | 7.1 | Acetic Acid | 15 | ≥6.0, ≥6.3 |
| 2 | 3.84 | 75 mM Ace | 5.7–5.9 | Acetic Acid | 5 | ≥5.9, ≥6.0 |
| 7 | 3.85 | 100 mM Gly, 200 mM Ace | 7.1 | Acetic Acid | 5 | ≥5.1, ≥5.3 |
| 6 | 3.85 | 75 mM Ace | 6.6–7.1 | Acetic Acid | 5 | ≥5.3, ≥5.6 |
| 9 | 3.85 | 75 mM Ace | 4.6 | Acetic Acid | 5 | ≥6.6, ≥6.9 |
| 2 | 3.86 | 75 mM Ace | 5.7–5.9 | Acetic Acid | 5 | ≥5.9, ≥6.0 |
| 5 | 3.85, 3.90 | 100 mM Gly, 200 mM Ace | 4–6 | Acetic Acid | 30 | ≥4.6, ≥4.6 |
| 4 | 3.90 | 100 mM Gly | 5.8 | Acetic Acid | 30 | ≥5.9, ≥6.4 |
| 1 | 3.96, 3.97 | 450 mM Ace, 100 mM NaCl | 5.6 | Acetic Acid | 5 | ≥7.3, ≥7.3 |
Gly: Glycine, Ace: Acetate.