Reconciliation of Ingredients, Extractables, and Targeted Extractables
| Component | Ingredient1 | Extractable2 | Targeted Extractable |
|---|---|---|---|
| Bottle (PE) | Antioxidants3 | Irganox 1076 | Irganox 1076 |
| 4-Nonylphenol isomers | 4-Nonylphenol isomers | ||
| Trinonylphenolphosphite | Trinonylphenolphosphite | ||
| Trinonylphenolphosphate | — | ||
| Cap (PP) | Antioxidants3 | Irganox 1010 | Irganox 10105 |
| Irgafos 168 | Irgafos 1685 | ||
| Irgafos 168 oxide | Irgafos 168 oxide5 | ||
| Catalyst3 | Ethyl-4-ethoxybenzoate | Ethyl-4-ethoxybenzoate | |
| Antistat3 | Monostearin | Monostearin6 | |
| Liner (rubber) | Brominated isobutylene isoprene copolymer | Br, B | — |
| Hydrocarbon Oligomers | C21 Hydrocarbon Oligomer | ||
| Octadecane, Octacosane, Tetracosane, Docosane | — | ||
| Calcined aluminosilicate | Al, Si | — | |
| Titanium dioxide | Ti | — | |
| Zinc oxide | Zn | — | |
| Calcined magnesium oxide | Mg | — | |
| Processing aids3 | Palmitic acid | Palmitic acid8 | |
| Stearic acid | Stearic acid8 | ||
| 10-Oxa-octadecanoic acid | — | ||
| Oleamide | — | ||
| Nonadecanoic acid | — | ||
| Hexadecanamide | — | ||
| Parafinnic oil | — | — | |
| Polyethylene | — | — | |
| SRF Carbon black mixture | — | — | |
| Unknown source | Dimethylterephthalate | — | |
| 1-(4-Morpholinyl)-octanoic acid | — | ||
| Morpholine | — | ||
| Label adhesive | Ethoxylated 2,4,7,9-Tetra-methyl-5-decyn-4,7-diol | 2,4,7,9-Tetra-methyl-5-decyn-4,7-diol | 2,4,7,9-Tetramethyl-5-decyn-4,7-diol |
| Dioctylsulfosuccinate, sodium salt | Dioctylsulfosuccinate, sodium salt | Dioctylsulfosuccinate, sodium salt5 | |
| Surfynol PSA 336 surfactant | — | — | |
| — | — | Benzophenone7 | |
| Label, ink | Irgacure 369 | — | — |
| Irgacure 1173 | — | Irgacure 11734 | |
| Trimethylolpropane triacrylate | — | — | |
| Tripropyleneglycol diacrylate | — | Dipropyleneglycol diacrylate4 | |
| 3-Glyceryl triacrylate (propoxylated) | — | — | |
| Modified polyester | — | — | |
| Pigments | — | — | |
| Label, biocide | Chloro-2-methyl-4-isothiazolin-3-one | — | |
| 3-Methyl-4-isothiazolin-3-one | 5-Ethyl-n-propylthiazole | — | |
| Magnesium chloride | — | — | |
| Magnesium nitrate | — | — | |
| Copper nitrate | — | — | |
| Label | Unknown | 1,(1,4-Dimethyl)-3-cyclohexen-1-yl) Ethanone | — |
| N-acetyl-N-(hydroxyl phenyl)-butanamide | — | ||
| 2-Propenoic acid, 2-ethylhexyl ester | — |
↵1 As specified by the component's vendor; see Table V.
↵2 As revealed by a controlled extraction study; see Table VI.
↵3 Although this ingredient was not specified by the component's vendor, this ingredient is commonly employed with this type of material.
↵4 Targeted as a spiked compound.
↵5 Although these extractables were targeted, their leaching was limited and their levels in the fill solutions were at or near the analytical method's quantitation limit. Thus, leaching (migration) profiles were not generated for these extractables.
↵6 Although this extractable was targeted, it undergoes transesterification in the presence of IPA. Thus leaching (migration) profiles for this extractable were not generated.
↵7 Although this extractable was not linked to the label by either its vendor or in the extraction study, it was added to the label as a spiked target due to its known association with label adhesives and its well-documented migration and leaching behavior.
↵8 Although these extractables were targeted, the resulting data suggested that analytical issues were encountered during the testing of the fill solutions. Thus, leaching (migration) profiles were not generated for these extractables.