Derivation of the Hazard Threshold (HT)
| Extractable | CAS RN | Basis for HT | Ref. | Values for Uncertainty Factors | |||
|---|---|---|---|---|---|---|---|
| UF1 | UF2 | UF3 | UF4 | ||||
| Silicic acid | 10193-36-9 | NOAEL for soluble silicates (rat, oral, 90 days); 227 mg/kg/day | 31 | 10 | 5 | 5 | 10 |
| Dodecamethylpentasiloxane | 141-63-9 | NOEL (rat, oral, 28 days); 1500 mg/kg/day | 7 | 10 | 5 | 10 | 4 |
| Tetradecamethylheptasiloxane | 19095-23-9 | Read across from 141-63-9 | — | — | — | — | — |
| Methycyclohexylsilanediol | 18295-72-2 | NOEL (rat, oral, read across from cyclohexyl-dimethoxymethylsilane, 17865-32-6); 62.5 mg/kg/day | 8 | 10 | 5 | 10 | 5 |
| 1,1-Dicyclopentylsilanediol | 211495-85-1 | NOEL (rat, oral, 90 day repeat dose); 40 mg/kg/day | 9 | 10 | 5 | 5 | 5 |
| Benzoic acid | 65-85-0 | NOAEL (rat, oral, 4 generation study); 750 mg/kg/day | 10 | 10 | 5 | 1 | 1 |
| Nonanoic acid | 112-05-0 | LD50 (mouse, i.v.); 224 mg/kg/day | 11 | 10 | 12 | 25 | 1 |
| Lactic acid | 50-21-5 | NOAEL (mouse, oral, maternal toxicity/teratogenicity); 570 mg/kg/day | 13 | 10 | 12 | 5 | 2 |
| Myristic acid | 544-63-8 | LD50 (rat, oral); 10000 mg/kg/day | 13 | 10 | 5 | 25 | 10 |
| Pentadecanoic acid | 1002-84-2 | Read across from 112-05-0 | — | — | — | — | — |
| Palmitic acid | 57-10-3 | LD50 (rat, oral); 10000 mg/kg/day | 14 | 10 | 5 | 25 | 2 |
| Oleic acid | 112-80-1 | NOAEL (rat, oral); 7500 mg/kg/day | 15 | 10 | 5 | 10 | 2 |
| Stearic acid | 57-11-4 | LD50 (human, oral); 14286 mg/kg/day | 16 | 10 | 1 | 25 | 10 |
| 7,9-Di-tert-butyl-1-oxaspiro(4,5)-deca-6,9-diene-2,8-dione | 82304-66-3 | Read across from 20170-32-5 | — | — | — | — | — |
| Methyl-3-[4-hydroxy-3,5-bis(2-methyl-2-propanyl)phenyl]-propanoate | 6386-38-5 | Read across from 20170-32-5 | — | — | — | — | — |
| 3-(3-5-di-tert-butyl-1-hydroxy-4-oxo-2,5-cyclohexadiene-1-yl)propanoic acid | 83237-15-4 | Read across from 20170-32-5 | — | — | — | — | — |
| 3,5-Bis(1,1-dimethylethyl)-4-hydroxy-benzenepropanoic acid | 20170-32-5 | NOAEL (rat, oral, 13 week); 50 mg/kg/day | 7 | 10 | 5 | 5 | 10 |
| 2,6-Di-tert-butyl-4-methylene-cyclohexa-2,5-dien-1-one | 2607-52-5 | Read across from 20170-32-5 | — | — | — | — | — |
| 2,4-Di-tert-butylphenol | 96-76-4 | NOAEL (rat, oral, 28 day); 75 mg/kg/day | 17 | 10 | 5 | 5 | 10 |
| Butylated Hydroxytoluene (BHT) | 128-37-0 | NOAEL (mouse, oral, 21 day); 660 mg/kg/day | 18, 19 | 10 | 12 | 10 | 1 |
| Irgafos 168 Phosphate | 95906-11-9 | Read across from Irgafos 168 (31570-04-4): LOAEL (rat, oral, 2-generation); 107 mg/kg/day | 20 | 10 | 5 | 1 | 10 |
| Erucamide + related substances | 112-84-5 | NOAEL (rat, oral, 4 week); 7100 mg/kg/day | 21 | 10 | 5 | 10 | 5 |
| Hexadecanamide | 629-54-9 | NOAEL (rat, oral, maternal and fetal); 1000 mg/kg/day | 7 | 10 | 5 | 1 | 10 |
| 9-Octadeceneamide | 301-02-0 | NOAEL (rat, oral, 5 days); 100 mg/kg/day | 7 | 10 | 5 | 10 | 10 |
| Urea | 57-13-6 | LDLo (mouse, i.v.); 4600 mg/kg/day | 22 | 10 | 12 | 15 | 5 |
| Glycerol | 56-81-5 | NOAEL (rat, oral); 10,000 mg/kg/day | 23 | 10 | 5 | 10 | 10 |
| Ethyl-4-ethoxybenzoate | 23676-09-7 | LD50 (rat, oral, acute); 1649 mg/kg/day | 7 | 10 | 5 | 25 | 10 |
| 1,4-Dithioerythritol | 3483-12-3 | LD50 (rat, oral); 400 mg/kg | 24 | 10 | 5 | 25 | 10 |
| Dodecanol | 112-53-8 | NOAEL (rat, oral, 37 day); 100 mg/kg/day | 25 | 10 | 5 | 10 | 1 |
| Dodecyl acrylate | 2156-97-0 | NOAEL (rat, oral, sub-chronic, read across from butyl acrylate); 84 mg/kg/day | 26 | 10 | 5 | 5 | 10 |
| Dibutyl phthalate | 84-74-2 | LOAEL (rat, oral, 21 days); 1047 mg/kg/day | 27 | 10 | 5 | 10 | 10 |
| Diethyl phthalate | 84-66-2 | NOAEL (mouse, oral, 2 weeks); 10,000 mg/kg/day | 28 | 10 | 12 | 10 | 10 |
| Stearyl alcohol | 112-92-5 | NOAEL (rat, oral, 28 days); 1000 mg/kg/day | 29 | 10 | 5 | 10 | 4 |
| Ethoxylated Amines (total), Atmer 163 | 71786-60-2 | TDLo (rat, oral); 500 mg/kg/day | 30 | 10 | 5 | 15 | 10 |