TABLE I

Prepared Placebo Solutions (55 runs total)

BufferpHTonicity AgentSurfactant
Sodium Acetate (10 mM and 20 mM)4.5, 5.0, 5.5Sodium chloride (75, 150 mM)Polysorbate 80 (0.02%, 0.06%)
4.5, 5.0, 5.5Mannitol (2.5%, 5.0%)Polysorbate 80 (0, 0.02%, 0.06%)
Sodium Citrate (10 mM and 20 mM)5.5, 6.0, 6.5Sodium chloride (75, 150 mM)Polysorbate 80 (0.02%, 0.06%)
5.0, 5.5, 6.0, 6.5Mannitol (2.5%, 5.0%)Polysorbate 80 (0, 0.02%, 0.06%)
Histidine (10 mM and 20 mM)5.5, 6.0, 6.5Sodium chloride (75, 150 mM)Polysorbate 80 (0.02%, 0.06%)
5.0, 5.5, 6.0, 6.5Mannitol (2.5%, 5.0%)Polysorbate 80 (0, 0.02%, 0.06%)