Equations Generated from the Best Fit Trend Lines Obtained from a Plot of the Isopropanol/Water Proportion Versus the Resulting Log P Values from Table V for Each Extractable Obtained for the 25%, 40%, 55%, and 70% Isopropanol Extraction Media. By adding the Log P values for the quantifiable extractables from the lyophilized drug product from Table IV, the percentage of isopropanol in the extraction solvent required to mimic the extraction power of the lyophilized drug product is determined.
| Compound | Equation | r2 | Required Percent of Isopropanol in Extraction Solvent |
|---|---|---|---|
| C13H24 Oligomer | y = 0.0008 x2 − 0.1199 x + 6.0961 | 1.00 | 50.0 |
| C13H23Br Oligomer 2 | y = 0.0011 x2 − 0.1562 x + 6.9011 | 1.00 | 38.8 |
| C21H40 Oligomer | y = 0.0008 x2 − 0.1386 + 7.5328 | 0.99 | 50.0 |
| C21H39Br Oligomer 1 | y = 0.0002 x2 − 0.0824 x + 6.2022 | 0.97 | 48.1 |
| C21H39Br Oligomer 2 | y = −0.056 x + 5.46 | 0.98 | 49.3 |