TABLE II

Selected Samples for Further Study Based on Range of Glide Force and Excipients

Run No.	Buffer	Buffer Concentration (mM)		Buffer pH		Tonicity Agent	Tonicity Concentration/Ionic Strength		PS80 Concentration (%)		Ave Glide Force (N) at 3 M 25 °C
54	Citrate	Low	10	Low	5.5	Mannitol	High	5%	None	0	1.86
36	Histidine	Low	10	Mid	6	Mannitol	High	5%	None	0	1.91
55^*	Citrate	Low	10	Mid	6	Mannitol	High	5%	None	0	2.06
43	Citrate	Low	10	Mid	6	NaCl	High	150 mM	Low	0.02	2.26
26	Histidine	High	20	Mid	6	NaCl	High	150 mM	High	0.06	2.28
14	Acetate	High	20	High	5.5	NaCl	High	150 mM	High	0.06	2.33
12	Acetate	Low	10	High	5.5	NaCl	Low	75 mM	Low	0.02	2.39
38	Citrate	Low	10	Low	5.5	Mannitol	High	5%	High	0.06	2.75
53	Citrate	Low	10	VLow	5	Mannitol	High	5%	High	0.06	2.81
33	Histidine	High	20	High	6.5	Mannitol	High	5%	High	0.06	3.65
34	Histidine	Low	10	VLow	5	Mannitol	High	5%	High	0.06	4.91
11	Acetate	High	20	Mid	5	Mannitol	Low	2.5%	Low	0.02	5.03
5	Acetate	High	20	Low	4.5	Mannitol	High	5%	High	0.06	5.37