Effect of Contact Material on Polysorbate 80 Degradation, 7 days at 25 °C1
| Sample | Time Point | Contact Material | |||
|---|---|---|---|---|---|
| Glass (Control) | Bag | Stainless Steel | Stainless Steel + N2 | ||
| Polysorbate 80 Content | 0 | 0.06% | 0.06% | 0.06% | 0.06% |
| 7 days | 0.06% | 0.06% | 0.005%1 | 0.05% | |
| Appearance | 0 | Clear & colorless | Clear & colorless | Clear & colorless | Clear & colorless |
| 7 days | Clear & colorless | Clear & colorless | Pale yellow | Clear & colorless | |
↵1 LC-MS indicated 1.9% of intact (i.e., un-oxidized) oleic acid.