Survey Results for the Application of Affinity Capture Chromatography within Biopharma
| Utilization of Affinity Capture Chromatography Processes in Biopharma | • All survey respondents use an affinity capture resin as a product purification step. |
| • A majority of respondents, 11 of 14, apply affinity capture as the primary purification capture step. | |
| • A vast majority (13/14 respondents) use standard, off-the-shelf resin types. Examples include MabSelect™ (Select, Xtra, SuRe), ProSep® (vA, Ultra Plus, Ultra-pre-packed). | |
| • Specialized resins may be required in some cases. | |
| • Choice of resin type is product-dependent. | |
| • Mixture of traditional and continuous processing applications. | |
| Process Applications | • Resin is product-dedicated. |
| • Sub-cycles may be employed to complete the purification of one batch. | |
| • Resin may be used in short or long processing campaigns. | |
| • Lifetime is typically limited by maximum number of load cycles. | |
| • Resin may be stored between manufacturing campaigns (some exceptions applied). |