Structural Changes of the Mixed or Spray-Dried mAb, as Indicated by the Amount of β-Sheets Measured Using FTIR
| Formulation | Stress Model/Sample | % β sheet |
|---|---|---|
| mAb A2 | Control | 54.9 |
| Mixed—Supernatant | 54.9 | |
| Mixed—Pellet | 50.0 | |
| mAb B | Control | 55.9 |
| Mixed—Supernatant | 55.3 | |
| Mixed—Pellet | 47.7 | |
| Spray-dried—Supernatant | 54.8 | |
| Spray-dried—Pellet | 47.3 | |
| mAb C | Control | 54.7 |
| Mixed—Supernatant | 54.6 | |
| Mixed—Pellet | 44.5 | |
| Spray-dried—Supernatant | 54.6 | |
| Spray-dried—Pellet | 32.5 |