Alternate Virus-Spiking Strategies Viral Clearance Study Results (*Based on Average of Bracketed Spikes (within 1 log)
| Run | Spike 1 | Spike 2 | Spike 3 | Totals | ||||
|---|---|---|---|---|---|---|---|---|
| mAb Volume (mL) | Log Reduction Value (LRV) | mAb Volume (mL) | LRV | mAb Volume (mL) | LRV | Estimated Total Viral Load (log10 TCID)* | LRV | |
| Control-high spike | 734 | ≥5.94 | (N/A) | 8.48 | ≥5.94 | |||
| Control-low spike | 726 | ≥3.64 | (N/A) | 6.17 | ≥3.64 | |||
| Bracketed | 30 | ≥6.05 | Protein Only (670 mL) | 30 | ≥5.10 | 7.20 | ≥5.80* | |
| Variable bracketed | 30 | ≥5.04 | 665 | ≥4.06 | 30 | ≥4.98 | 6.79 | ≥5.94* |