TABLE II

Viral Clearance Comparison Between New and Lifetime Protein A Resin

Sample	Total Log₁₀ TCID₅₀ or PFU of Indicated Sample
	Case I			Case II				Case III
	Lifetime Resin	New Resin		Lifetime Resin		New Resin		Lifetime Resin		New Resin
	Lifetime Resin	Exp.-1	Exp.-2	Exp.-1	Exp.-2	Exp.-1	Exp.-2	Exp.-1	Exp.-2	Exp.-1	Exp.-2
Spiked Load	8.56	8.21	7.79	10.09	9.96	8.90	8.98	8.68	8.93	10.60	9.72
Flow-through	8.56	7.97	7.85	9.46	9.71	8.84	8.96	8.61	8.98	11.37	not done^{^a}
Combined Wash	6.79	7.34	7.27	8.27	8.15	7.75	7.75	6.88	7.13	9.32	not done^{^a}
Front Side	3.74	4.13	3.53	4.34	4.68	4.18	4.15	4.75	4.63	5.40	3.77
Mainstream	3.70	4.13	3.19	7.28	7.58	6.94	7.04	7.36	7.12	9.13	7.89
Back Side	<2.72	3.52	<2.36	5.52	5.59	5.31	4.47	5.27	5.27	7.21	5.71
Hold Control	8.50	7.91	7.82	9.71	9.59	8.54	8.50	8.81	8.93	10.85	9.22
LRF Achieved^{^b}	4.86	4.08	4.60	2.81	2.38	1.96	1.94	1.32	1.81	1.47	1.83

↵a These two samples were not titrated to determine virus titers.
↵b LRF achieved = Total log₁₀ TCID₅₀ or PFU of spiked load − total log₁₀ TCID₅₀ or PFU of mainstream.