Evaluation of Rubber Stopper Temperature Limits in Lyo Stoppers with 20 mm Vial Neck Size
| Container Closure Integrity | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Vial# | Leak Rate (mbar × L/s) | T (°C) | Leak Rate (mbar × L/s) | T (°C) | Leak Rate (mbar × L/s) | T (°C) | Leak Rate (mbar × L/s) | T (°C) | Leak Rate (mbar × L/s) | T (°C) |
| 1 | Tight | 22.9 | Tight | −20.2 | Tight | −31.2 | Tight | −41.0 | Tight | −60.3 |
| 2 | Tight | 23.2 | Tight | −21.6 | Tight | −31.6 | Tight | −41.7 | Tight | −60.0 |
| 3 | Tight | 22.4 | Tight | −22.5 | Tight | −31.0 | Tight | −42.7 | Un-tight | −60.5 |
| 4 | Tight | 22.2 | Tight | −21.7 | Tight | −31.4 | Tight | −41.3 | Tight | −59.8 |
| 5 | Tight | 24.8 | Tight | −22.5 | Tight | −32.4 | Tight | −41.5 | Un-tight | −60.3 |
Shaded cells show 1%–100% leaking vials (leak).