Blood clearance and organ deposition of intravenously administered colloidal particles. The effects of particle size, nature and shape

https://doi.org/10.1016/0378-5173(82)90113-2Get rights and content

Abstract

The blood clearance and organ deposition of polystyrene and cellulose (DEAE) particles have been studied in the rabbit using labelled material and the technique of gamma scintigraphy in order to investigate the importance of particle size, shape and nature. Small (1.27 μm diameter) polystyrene microspheres were taken up by the reticuloendothelial system of the liver, while large polystyrene particles (15.8 μm diameter) were mechanically filtered by capillary beds of the lungs. Cellulose microspheres and fibres were also taken up into lung tissue. Large cellulose fibres, 30 μm diameter, proved to be toxic whereas large cellulose microspheres were well tolerated. The implications for drug targeting are discussed.

References (21)

  • R.C. Oppenheim

    Solid Colloidal drug delivery systems: tianoparticles

    Int. J. Pharm.

    (1981)
  • H.G. Schroeder et al.

    Distribution of radiolabeled subvisible microspheres after intravenous administration to Beagle dogs

    J. Pharm. Sci.

    (1978)
  • L.H. Archibald

    Measurement of gastric blood flow with radioactive microspheres

    J. Appl. Physiol.

    (1975)
  • T.K. Chandhuri et al.

    Autoradiographic studies of distribution in the liver of 198Au and 99mTc-sulphur colloids

    Radiology

    (1973)
  • M.A. Davis
  • M.A. Davis et al.

    Pulmonary perfusion imaging: active toxicity and safety factors as a function of particle size

    J. Nucl. Med.

    (1978)
  • M.J. Groves et al.

    The relevance of Pharmacopoeial Particulate Matter Limit tests

    Drug Dev. Commun.

    (1976)
  • J.G. Hardy et al.

    Radionuclide imaging in pharmaceutical, physiological and pharmacological research

    Clin. Phys. Physiol. Meas.

    (1981)
  • Y. Huh et al.

    A radiation induced bonding of iodine at the surface of uniform polystyrene particles

    Radiat. Res.

    (1974)
  • L. Illum et al.

    Cellulose microspheres as a sustained release system for parenteral administration

    Int. J. Pharm.

    (1982)
There are more references available in the full text version of this article.

Cited by (243)

  • Impact of mechanical stress on flexible tubing used for biomedical applications: Characterization of the damages and impact on the patient's health

    2022, Journal of the Mechanical Behavior of Biomedical Materials
    Citation Excerpt :

    There is an impact of their size and their shape on the risk encountered by the patient (Ilium et al., 1982); for example, smaller glass beads produced greater pulmonary dysfunction, may be due to higher systemic effect (Kusaka et al., 2014). The distribution of particles in the body is moreover size dependent: some authors showed the larger particles were retained in the lungs (12 μm) but the smaller ones were retained in organs (liver and spleen) (Ilium et al., 1982; Kanke et al., 1980). Pulmonary vessel can be obstructed by large fibers and this was responsible of death using rabbit as a model.

  • Simultaneous infusion of two incompatible antibiotics: Impact of the choice of infusion device and concomitant simulated fluid volume support on the particulate load and the drug mass flow rates

    2022, International Journal of Pharmaceutics
    Citation Excerpt :

    The American Society of Health-System Pharmacists defines drug incompatibility as the formation of a physical or visual compatibility and/or decomposition of one or more components by more than 10% in less than 24 h under the specified conditions, (Trissel, 2018). The main risk associated with drug incompatibility is partial or complete catheter blockage (Benlabed et al., 2019; Boehne et al., 2013; Jack et al., 2012; Lehr et al., 2002; McNearney et al., 2003; Sasse et al., 2015), which in turn leads to delayed infusion, drug loss, the formation of toxic components, the deposition of particles in key organs (kidney, liver, and lungs) and particle-induced mechanical damage to blood vessels and systemic inflammatory response syndromes (Ilium et al., 1982; Jack et al., 2012). The present in vitro study replicated one of the intravenous infusion set-ups used in the critical care unit at Saint-Antoine Hospital (Paris, France), with the combined infusion of amikacin, vancomycin and piperacillin/tazobactam through the medial lumen of a three-lumen catheter.

View all citing articles on Scopus
View full text