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Phase Behavioral Effects on Particle Formation Processes Using Supercritical Fluids

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Abstract

The application of supercritical fluid (SF) processing in pharmaceutical research is increasing particularly in the field of particle formation for drug delivery systems. The SF processes have benefits over the existing particle formation methods in terms of improved control, flexibility and operational ease. This review highlights the fundamental concepts of fluid phase behaviour and their influence on the various processes involving particle formation with supercritical fluids. Several phase behaviour systems are discussed to provide an insight into the factors influencing the process paths and their effects on the characteristics of the particles.

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Authors and Affiliations

  1. Bradford Particle Design Limited, 49, Listerhills Science Park Campus Road, Bradford, BD7 1HR, UK

    Srinivas Palakodaty & Peter York

  2. Drug Delivery Group, Pharmaceutical Technology, School of Pharmacy, University of Bradford, Bradford, BD7 1HR, UK

    Srinivas Palakodaty & Peter York

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  1. Srinivas Palakodaty
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Correspondence to Srinivas Palakodaty.

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Palakodaty, S., York, P. Phase Behavioral Effects on Particle Formation Processes Using Supercritical Fluids. Pharm Res 16, 976–985 (1999). https://doi.org/10.1023/A:1011957512347

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