Skip to main content
SpringerLink
Log in

Chitosan as a Novel Nasal Delivery System for Peptide Drugs

  • Published:
Pharmaceutical Research Aims and scope Submit manuscript

Abstract

A nasal solution formulation of the cationic material chitosan was shown to greatly enhance the absorption of insulin across the nasal mucosa of rat and sheep. The absorption promoting effect was concentration dependent with the optimal efficacy obtained for concentrations higher than 0.2% and 0.5% in rats and sheep, respectively. The absorption promoting effect was reversible with time in a “pulse-chase” study. Histological examination of the nasal mucosa of rats exposed to a chitosan solution for 60 minutes showed little change.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

REFERENCES

  1. Y. Sawayanagi, N. Nambu and T. Nagai. Directly compressed tablets containing chitin or chitosan in addition to mannitol. Chem. Pharm. Bull. 30: 4216–4218 (1982).

    Google Scholar 

  2. Y. Sawayanagi, N. Nambu and T. Nagai. The use of chitosan for sustained release preparations of water soluble drugs. Chem. Pharm. Bull. 30: 4213–4215 (1982).

    Google Scholar 

  3. T. Imai, S. Shiraishi, H. Saito and M. Otagiri. Interaction of indomethacin with low molecular weight chitosan and improvements of some pharmaceutical properties of indomethacin by low molecular weight chitosan. Int. J. Pharm. 67: 11–20 (1991).

    Google Scholar 

  4. K. Takayama, M. Hirata, Y. Machida, T. Masada, T. Sannan and T. Nagai. Effect of interpolymer complex formation on bioadhesive proterty and drug release phenomenon of compressed tablet consisting of chitosan and sodium hyaluronate. Chem. Pharm. Bull. 38: 1993–1997 (1990).

    Google Scholar 

  5. S. Miyazaki, K. Ishii and T. Nadai. The use of chitin and chitosan as drug carriers. Chem. Pharm. Bull. 29: 3067–3069 (1981).

    Google Scholar 

  6. S. Miyazaki, H. Yamaguchi, C. Yokouchi, M. Takada and W-M. Hou. Sustained release and intragastric-floating granules of indomethacin using chitosan in rabbits. Chem. Pharm. Bull. 36: 4033–4038 (1988).

    Google Scholar 

  7. K. Arai, T. Kinumaki and T. Fujita. Toxicity of chitosan. Bull. Tokai Reg. Fish. Lab. 43: 89–94 (1968).

    Google Scholar 

  8. C-M. Lehr, J. A. Bouwstra, E. H. Schacht and H. E. Junginger. In vitro evaluation of mucoadhesive properties of chitosan and some other natural polymers. Int. J. Pharm. 78: 43–48 (1992).

    Google Scholar 

  9. D. T. O'Hagan and L. Illum. Absorption of peptides and proteins from the respiratory tract and the potential for development of locally administered vaccine. CRC Crit. Rev. Ther. Drug Carrier Syst. 7: 35–97 (1990)

    Google Scholar 

  10. L. Illum, H. Jorgensen, H. Bisgaard, O. Krogsgaard and N. Rossing. Bioadhesive microspheres as a potential nasal drug delivery system. Int. J. Pharm. 39: 189–199 (1987).

    Google Scholar 

  11. L. Illum, N. F. Farraj, H. Critchley and S. S. Davis. Nasal administration of gentamicin using a novel microsphere delivery system. Int. J. Pharm. 46: 261–265 (1988).

    Google Scholar 

  12. L. Illum, N. F. Farraj, S. S. Davis, B. R. Johansen and D. T. O'Hagan. Investigation of the nasal absorption of biosynthetic human growth hormone in sheep—use of a bioadhesive microsphere delivery system. Int. J. Pharm. 63: 207–211 (1990).

    Google Scholar 

  13. N. F. Farraj, B. R. Johansen, S. S. Davis and L. Illum. Nasal administration of insulin using bioadhesive microspheres as a delivery system. J. Control. Rel. 13: 253–261 (1990).

    Google Scholar 

  14. L. Illum and S. S. Davis. Intranasal insulin. Clinical Pharmacokinetics. Clin. Pharmacokinet., 23: 30–41 (1992).

    Google Scholar 

  15. P. Edman, E. Bjork and L. Ryden. Microspheres as a nasal delivery system for peptide drugs. J. Control. Rel. 21: 165–172 (1992).

    Google Scholar 

  16. S. G. Chandler, L. Illum and N. W. Thomas. Nasal absorption in the rat. I. An in situ method for the demonstration of histological effects resulting from the administration of nasal formulations. Int. J. Pharm. 70: 12–27 (1991).

    Google Scholar 

  17. S. Hirai, T. Yashida and H. Mima. Mechanism for the enhancement of the nasal absorption of insulin by surfactants. Int. J. Pharm. 9: 173–184 (1981).

    Google Scholar 

  18. D. N. Granger, P. R. Kvietys, M. A. Perry and A. E. Taylor. Charge selectivity of rat intestinal capillaries. Influence of polycations. Gastroenterology 91: 1443–1446 (1986).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Albert Einstein Centre, DanBioSyst UK Ltd, Highfields Science Park, Nottingham, NG7 2TN, UK

    Lisbeth Illum, Nidal F. Farraj & Stanley S. Davis

Authors
  1. Lisbeth Illum
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nidal F. Farraj
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stanley S. Davis
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Illum, L., Farraj, N.F. & Davis, S.S. Chitosan as a Novel Nasal Delivery System for Peptide Drugs. Pharm Res 11, 1186–1189 (1994). https://doi.org/10.1023/A:1018901302450

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1023/A:1018901302450

Search

Navigation