In vivo and in vitro degradation of poly(3-hydroxybutyrate) in rat

Biomaterials. 1991 Apr;12(3):309-12. doi: 10.1016/0142-9612(91)90039-d.

Abstract

The inflammatory activity and biodegradation of poly(3-hydroxybutyrate) were examined. Poly(3-hydroxybutyrate) sheet did not cause any inflammation in the chorioallantoic membrane of the developing egg. The i.v. injection of 14C-labelled poly(3-hydroxybutyrate) granules showed that 86, 2.5 and 2.4% of the total radioactivity administered were distributed in the liver, spleen and lung, respectively, and the radioactivity decreased slowly but steadily in most tissues examined during 2 month. Crude extracts of rat tissues showed that the activity degraded the poly(3-hydroxybutyrate) granules in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biocompatible Materials*
  • Biodegradation, Environmental
  • Carbon Radioisotopes
  • Chorion / cytology
  • Hydrogen-Ion Concentration
  • Hydroxybutyrates* / administration & dosage
  • In Vitro Techniques
  • Injections, Intravenous
  • Male
  • Polyesters* / administration & dosage
  • Rats
  • Rats, Inbred Strains
  • Spectrophotometry
  • Tissue Distribution

Substances

  • Biocompatible Materials
  • Carbon Radioisotopes
  • Hydroxybutyrates
  • Polyesters
  • poly-beta-hydroxybutyrate